Nevasaari K, Kärki N T
Arch Int Pharmacodyn Ther. 1976 Jun;221(2):283-93.
The effect of acetylcholine on bile flow was studied in isolated perfused rat liver. Acetylcholine added into the perfusion medium altered bile flow in a way analogous to mechanical clamping and opening of the common bile duct. This effect was potentiated by physostigmine and antagonized by atropine. The results suggest that acetylcholine can pass from portal sinusoidal blood into the biliary tract, possibly through the terminal bars of bile canaliculi, and cause an obstruction in the biliary tree. Suggested mechanism could explain the observed decreased and increased bile flow caused by cholinergic drugs or vagal stimulation in the earlier experiments.
在离体灌注的大鼠肝脏中研究了乙酰胆碱对胆汁流量的影响。向灌注介质中添加乙酰胆碱后，胆汁流量的改变方式类似于机械夹闭和开放胆总管。毒扁豆碱可增强这种作用，而阿托品则可拮抗这种作用。结果表明，乙酰胆碱可能通过胆小管的终末连接从门静脉窦状隙血液进入胆道，并导致胆道树阻塞。所提出的机制可以解释早期实验中观察到的胆碱能药物或迷走神经刺激引起的胆汁流量减少和增加的现象。
