Raymond J, Kalach N, Bergeret M, Benhamou P H, Barbet J P, Gendrel D, Dupont C
Service Microbiologie, Hôpital Saint Vincent de Paul, Paris, France.
Antimicrob Agents Chemother. 1998 Jun;42(6):1334-5. doi: 10.1128/AAC.42.6.1334.
A prospective study was performed with 23 Helicobacter pylori-infected children (mean age, 9.5 +/- 4.4 years) with clinical symptoms of gastritis and positive results of culture and histologic examination of gastric biopsy specimens to evaluate the influence of antibiotic resistance on eradication. Positive children were treated for 4 weeks with lansoprazole and for 2 weeks with either amoxicillin-metronidazole or spiramycin (a macrolide)-metronidazole. At endoscopy 1 month after the discontinuation of therapy, the eradication rate and improvement of histologically related gastritis were significantly dependent on the susceptibility or the resistance of the infecting organism to metronidazole (83 versus 17% and 88 versus 16.6%, respectively). Pretreatment determination of the susceptibility is appropriate in any anti-H, pylori regimen, including one with metronidazole.
对23名幽门螺杆菌感染儿童（平均年龄9.5±4.4岁）进行了一项前瞻性研究，这些儿童有胃炎的临床症状，胃活检标本培养和组织学检查结果呈阳性，以评估抗生素耐药性对根除治疗的影响。阳性儿童接受兰索拉唑治疗4周，并用阿莫西林-甲硝唑或螺旋霉素（一种大环内酯类药物）-甲硝唑治疗2周。在治疗停止1个月后进行内镜检查时，根除率和组织学相关性胃炎的改善情况显著取决于感染菌对甲硝唑的敏感性或耐药性（分别为83%对17%和88%对16.6%）。在任何抗幽门螺杆菌治疗方案中，包括含甲硝唑的方案，治疗前测定敏感性都是合适的。
