罗红霉素在体外可抑制细胞因子的产生以及中性粒细胞与人类支气管上皮细胞的黏附。
Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro.
作者信息
Kawasaki S, Takizawa H, Ohtoshi T, Takeuchi N, Kohyama T, Nakamura H, Kasama T, Kobayashi K, Nakahara K, Morita Y, Yamamoto K
机构信息
Department of Medicine, School of Medicine, University of Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 1998 Jun;42(6):1499-502. doi: 10.1128/AAC.42.6.1499.
Abstract
We evaluated the effect of roxithromycin on cytokine production and neutrophil attachment to human airway epithelial cells. Roxithromycin suppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-macrophage colony-stimulating factor. It inhibited neutrophil adhesion to epithelial cells. Roxithromycin modulates local recruitment and activation of inflammatory cells, which may have relevance to its efficacy in airway diseases.
摘要
我们评估了罗红霉素对细胞因子产生以及中性粒细胞与人气道上皮细胞黏附的影响。罗红霉素抑制白细胞介素8（IL-8）、IL-6和粒细胞-巨噬细胞集落刺激因子的产生。它抑制中性粒细胞与上皮细胞的黏附。罗红霉素可调节炎症细胞的局部募集和激活，这可能与其在气道疾病中的疗效相关。
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