Praet J P, Peretz A, Mets T, Rozenberg S
Geriatric Unit, Universitair Ziekenhuis St. Pieter, Brussels, Belgium.
J Endocrinol Invest. 1998 Apr;21(4):263-7. doi: 10.1007/BF03347313.
A daily ingestion of 1000 to 1500 mg elemental calcium associated with vitamin D supplement is presently considered to be the adequate and least expensive therapy for senile osteoporosis. There exists only scarce data about calcium absorption with available calcium salts in elderly patients. We have compared the digestive absorption of calcium (Ca) citrate in soluble and solid form and calcium gluconolactate-carbonate in 15 young and 20 elderly, healthy women using the oral calcium loading test. The subjects were divided into two groups. In the first group, the absorption of solid Ca citrate (1000 mg Ca element) was compared to the absorption of Ca gluconolactate-carbonate (1000 mg Ca element) both in young (n = 7) and elderly women (n = 10). In the second group, the absorption of soluble Ca citrate (1000 mg Ca element) was compared to the absorption of Ca gluconolactate-carbonate (1000 mg Ca element) in young (n = 8) and elderly (n = 10) women. In the preload phase, basal calciuria was increased in elderly women (p < 0.01) although basal calcemia was similar in young and elderly women. After oral administration of the calcium salts, an increase in plasma Ca was observed in both groups which was greater for soluble Ca citrate and Ca gluconolactate than for solid Ca citrate. In young women, the increase in plasma calcium was significantly higher with soluble Ca citrate compared to Ca gluconolactate (p < 0.05). In elderly women, the postload calciuria was significantly higher for soluble Ca citrate (p < 0.05) and Ca gluconolactate (p < 0.05) compared to solid Ca citrate. A similar pattern was observed in young women, although it was not significant. In conclusion, an oral load of 1000 mg soluble Ca citrate and Ca gluconolactate-carbonate induces significant biochemical changes suggesting a better digestive absorption compared to Ca citrate in solid form, both in young and elderly women. We did not observe different response, between young and old patients.
目前认为，每日摄入1000至1500毫克元素钙并补充维生素D是治疗老年骨质疏松症的充分且最经济的疗法。关于老年患者对现有钙盐中钙的吸收情况，仅有少量数据。我们通过口服钙负荷试验，比较了15名年轻健康女性和20名老年健康女性对可溶性和固体形式的柠檬酸钙以及葡萄糖酸乳酸钙 - 碳酸盐的消化吸收情况。受试者被分为两组。在第一组中，比较了年轻女性（n = 7）和老年女性（n = 10）对固体柠檬酸钙（1000毫克钙元素）和葡萄糖酸乳酸钙 - 碳酸盐（1000毫克钙元素）的吸收情况。在第二组中，比较了年轻女性（n = 8）和老年女性（n = 10）对可溶性柠檬酸钙（1000毫克钙元素）和葡萄糖酸乳酸钙 - 碳酸盐（1000毫克钙元素）的吸收情况。在预负荷阶段，老年女性的基础尿钙增加（p < 0.01），尽管年轻女性和老年女性的基础血钙相似。口服钙盐后，两组均观察到血浆钙升高，其中可溶性柠檬酸钙和葡萄糖酸乳酸钙引起的升高幅度大于固体柠檬酸钙。在年轻女性中，与葡萄糖酸乳酸钙相比，可溶性柠檬酸钙使血浆钙升高更为显著（p < 0.05）。在老年女性中，与固体柠檬酸钙相比，可溶性柠檬酸钙（p < 0.05）和葡萄糖酸乳酸钙（p < 0.05）的负荷后尿钙显著更高。年轻女性中也观察到类似模式，尽管不显著。总之，口服1000毫克可溶性柠檬酸钙和葡萄糖酸乳酸钙 - 碳酸盐会引起显著的生化变化，表明与固体形式的柠檬酸钙相比，年轻女性和老年女性对其消化吸收更好。我们未观察到年轻患者和老年患者之间的不同反应。
