Gonnelli S, Cepollaro C, Camporeale A, Nardi P, Rossi S, Gennari C
Institute of Internal Medicine, University of Siena, Italy.
Calcif Tissue Int. 1995 Sep;57(3):175-7. doi: 10.1007/BF00310254.
Despite the potential utility of calcium supplementation and the availability of many calcium supplements in the market, there are few data concerning the absorbability of different calcium salts in different conditions. We have compared the acute metabolic responses following oral administration of calcium citrate (CC) or calcium gluconolactate and carbonate (CGC) given to 20 healthy perimenopausal women (aged 48-55 years). Ten women received two effervescent tablets of CC (each containing 500 mg of calcium) and 10 women received two effervescent tablets of CGC (each containing 500 mg of calcium). Before and on an hourly basis for 6 hours, serum total and ionized calcium, phosphate, and immunoreactive parathyroid hormone (iPTH) were measured. Urinary calcium and creatinine were also measured. Both calcium salts induced significant increase in serum total and ionized calcium and in urinary calcium excretion; they also significantly reduced circulating levels of iPTH. The analysis of ionized calcium and iPTH response curves to CC and CGC administration revealed a significantly greater bioavailability of CC compared with CGC. Our data suggest that CC could be prefered to CGC for its characteristics of absorbability and bioavailability.
尽管补钙具有潜在益处，且市场上有多种钙补充剂可供选择，但关于不同钙盐在不同条件下的吸收情况的数据却很少。我们比较了20名健康围绝经期女性（年龄48 - 55岁）口服柠檬酸钙（CC）或葡萄糖酸乳酸钙和碳酸钙（CGC）后的急性代谢反应。10名女性服用两片CC泡腾片（每片含500毫克钙），10名女性服用两片CGC泡腾片（每片含500毫克钙）。在服用前以及之后每小时测量一次，持续6小时，检测血清总钙、离子钙、磷酸盐和免疫反应性甲状旁腺激素（iPTH）。同时也测量尿钙和肌酐。两种钙盐均导致血清总钙和离子钙以及尿钙排泄显著增加；它们还显著降低了循环中的iPTH水平。对CC和CGC给药后的离子钙和iPTH反应曲线分析显示，与CGC相比，CC的生物利用度显著更高。我们的数据表明，就吸收性和生物利用度特性而言，CC可能比CGC更具优势。
