Pimentel J, Fernandes A, Pinto A E, Fonseca I, Moura Nunes J F, Lobo Antunes J
Laboratório de Neuropatologia, Serviço de Neurologia, Hospital de Santa Maria, Lisboa, Portugal.
Clin Neuropathol. 1998 May-Jun;17(3):141-6.
The few reports about clear cell meningiomas (CCM) point to an inordinate clinical aggressiveness despite their histological benignity. We studied 5 CCM aiming to assess their clinicopathological, cytometric, and ultrastructural features. Two patients were females and 3 males, with a mean age of 36 years. Two tumors were spinal, one of the cerebral convexity, one of the tentorium-clinoid region, and one of the base of the skull. The first 3 were totally removed and have not recurred for a mean follow-up time of 40 months. The tentorium-clinoid and the skull base tumors had radical subtotal and partial resections, and recurred after 16 and 1.5 months, respectively. All tumors but one, a non-recurrent one, presented no signs of histological anaplasia. The proliferative capacity, as assessed by MIB-1 staining index (SI), of recurrent tumors was slightly higher than that of those tumors that did not recur. All cases showed DNA diploid pattern. Amianthoid-type fibers were disclosed on ultrastructural study. CCM arose in patients younger than those with other variants of meningioma, the spinal canal and the posterior fossa were the common sites. Finally, intracranial tumors were linked to an aggressive behavior.
关于透明细胞脑膜瘤（CCM）的少数报道指出，尽管其组织学表现为良性，但临床侵袭性却异常高。我们研究了5例CCM，旨在评估其临床病理、细胞计量学和超微结构特征。2例患者为女性，3例为男性，平均年龄36岁。2例肿瘤位于脊髓，1例位于大脑凸面，1例位于小脑幕-床突区，1例位于颅底。前3例肿瘤被完全切除，平均随访40个月未复发。小脑幕-床突区和颅底肿瘤分别进行了根治性次全切除和部分切除，分别在16个月和1.5个月后复发。除1例未复发的肿瘤外，所有肿瘤均无组织学间变迹象。通过MIB-1染色指数（SI）评估，复发肿瘤的增殖能力略高于未复发肿瘤。所有病例均显示DNA二倍体模式。超微结构研究发现有石棉样纤维。CCM患者的发病年龄比其他类型脑膜瘤患者年轻，椎管和后颅窝是常见部位。最后，颅内肿瘤与侵袭性表现相关。
