McBride P, Schrott H G, Plane M B, Underbakke G, Brown R L
HEART Preventive Cardiology Program, University of Wisconsin Medical School, Madison 53715-1849, USA.
Arch Intern Med. 1998 Jun 8;158(11):1238-44. doi: 10.1001/archinte.158.11.1238.
Clinical trials demonstrate significant benefit from cholesterol management for patients with cardiovascular disease (CVD). National guidelines recommending goals for screening and treatment were published in 1993 and widely disseminated. This study examines cholesterol screening and management by primary care physicians after the guidelines were released.
Medical records and patient surveys provided data for 603 patients with CVD, aged 27 to 70 years, from 45 practices in 4 states during 1993 to 1995. Physician surveys measured estimated performance and other variables. Physician and patient factors associated with adherence, or lack of adherence, to national guidelines were examined using univariate and multivariate analyses.
A total of 199 patients (33%) with CVD were not screened with lipid panels, 271 patients (45%) were not receiving dietary counseling, and 404 (67%) were not receiving cholesterol medication. Only 84 patients (14%) with CVD had achieved the recommended low-density lipoprotein level of less than 2.58 mmol/L (100 mg/dL) and 302 (50%) had triglyceride levels lower than 2.26 mmol/L (200 mg/dL). Patients with a revascularization history and higher low-density lipoprotein and/or triglyceride levels were more likely to receive treatment, but other patient factors, including CVD risk factors, did not predict treatment. Physician specialty was not associated with differences in treatment, but physicians in practice for fewer years ordered more lipid panels.
Most patients with CVD in primary care were not receiving cholesterol screening and management as recommended by the National Cholesterol Education Program guidelines in the 2 years after their release. Increasing cholesterol screening and treatment should be a priority for practice quality improvement and could result in significant reductions in CVD events for high-risk patients.
临床试验表明,对心血管疾病(CVD)患者进行胆固醇管理可带来显著益处。1993年发布了推荐筛查和治疗目标的国家指南,并广泛传播。本研究调查了指南发布后基层医疗医生对胆固醇的筛查和管理情况。
1993年至1995年期间,从4个州的45家医疗机构获取了603例年龄在27至70岁之间的CVD患者的病历和患者调查数据。医生调查测量了估计的表现和其他变量。使用单变量和多变量分析检查与遵守或不遵守国家指南相关的医生和患者因素。
共有199例(33%)CVD患者未进行血脂检测,271例(45%)未接受饮食咨询,404例(67%)未接受胆固醇药物治疗。只有8�例(14%)CVD患者的低密度脂蛋白水平达到了推荐的低于2.58 mmol/L(100 mg/dL),302例(50%)的甘油三酯水平低于2.26 mmol/L(200 mg/dL)。有血管重建病史且低密度脂蛋白和/或甘油三酯水平较高的患者更有可能接受治疗,但包括CVD危险因素在内的其他患者因素并不能预测治疗情况。医生专业与治疗差异无关,但从业年限较短的医生开出的血脂检测单更多。
在国家胆固醇教育计划指南发布后的两年里,大多数基层医疗中的CVD患者未按照指南推荐接受胆固醇筛查和管理。增加胆固醇筛查和治疗应成为提高医疗质量的优先事项,这可能会显著降低高危患者的CVD事件发生率。