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2
Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway.胆汁酸对食管癌细胞中人黏蛋白MUC4的转录调控是启动子依赖性的，且涉及磷脂酰肌醇3激酶信号通路的激活。
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本文引用的文献

1
Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis.熊去氧胆酸治疗小儿进行性家族性肝内胆汁淤积症
Hepatology. 1997 Mar;25(3):519-23. doi: 10.1002/hep.510250303.
2
Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase.胆汁酸对肝细胞蛋白激酶C的激活作用：对胆固醇7α-羟化酶调节的影响
Am J Physiol. 1996 Aug;271(2 Pt 1):G293-303. doi: 10.1152/ajpgi.1996.271.2.G293.
3
Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes.牛磺熊去氧胆酸在分离的大鼠肝细胞中激活蛋白激酶C。
Gastroenterology. 1996 May;110(5):1553-63. doi: 10.1053/gast.1996.v110.pm8613063.
4
Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis.熊去氧胆酸对原发性胆汁性肝硬化患者生存率的影响。
Gastroenterology. 1996 May;110(5):1515-8. doi: 10.1053/gast.1996.v110.pm8613058.
5
Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver.微管参与灌注大鼠肝脏中肿胀诱导的牛磺胆酸盐跨细胞转运刺激过程。
Biochem J. 1993 Apr 15;291 ( Pt 2)(Pt 2):355-60. doi: 10.1042/bj2910355.
6
Protein kinase C isoenzymes: divergence in signal transduction?蛋白激酶C同工酶：信号转导中的差异？
Biochem J. 1993 Apr 15;291 ( Pt 2)(Pt 2):329-43. doi: 10.1042/bj2910329.
7
Ursodeoxycholate mobilizes intracellular Ca2+ and activates phosphorylase a in isolated hepatocytes.熊去氧胆酸可动员分离肝细胞内的钙离子，并激活磷酸化酶a。
Am J Physiol. 1993 Feb;264(2 Pt 1):G243-51. doi: 10.1152/ajpgi.1993.264.2.G243.
8
Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes.牛磺熊去氧胆酸对分离的大鼠肝细胞胞质Ca2+信号的影响。
Gastroenterology. 1993 Feb;104(2):604-12. doi: 10.1016/0016-5085(93)90433-d.
9
Regulated exocytosis.调节性胞吐作用
Biochem J. 1993 Jul 15;293 ( Pt 2)(Pt 2):305-16. doi: 10.1042/bj2930305.
10
Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat.新合成的肝细胞质膜蛋白在胆管结扎大鼠的转胞吞小泡中运输。
Gastroenterology. 1993 Aug;105(2):554-71. doi: 10.1016/0016-5085(93)90734-t.

胆汁酸对肝细胞信号传导和分泌的影响。

Effects of bile acids on hepatocellular signaling and secretion.

作者信息

Beuers U

机构信息

Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany.

出版信息

Yale J Biol Med. 1997 Jul-Aug;70(4):341-6.

PMID:9626754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2589332/
Abstract

Bile acids modulate hepatocellular signaling pathways in vitro at physiological concentrations. The present paper provides a brief overview of the effects of bile acids on three key messengers in liver cells: cytosolic free calcium, protein kinase A and protein kinase C.

摘要

胆汁酸在生理浓度下可在体外调节肝细胞信号通路。本文简要概述了胆汁酸对肝细胞中三种关键信使的影响：胞质游离钙、蛋白激酶A和蛋白激酶C。