Amitai Y, Zlotogorski Z, Golan-Katzav V, Wexler A, Gross D
Department of Pediatrics, Hadassah University Mt Scopus, Jerusalem, Israel.
Arch Neurol. 1998 Jun;55(6):845-8. doi: 10.1001/archneur.55.6.845.
To investigate the effects of acute low-level exposure to carbon monoxide on higher cognitive functions in healthy humans.
An empirical study of the effects of low-level exposure to carbon monoxide on higher cognitive functions in young healthy volunteers and a matched nonexposed control group.
A dormitory at the Hebrew University campus in Jerusalem, Israel.
Forty-five student volunteers who were exposed to carbon monoxide from residential kerosene stoves for 1.5 to 2.5 hours (air carbon monoxide concentrations of 17-100 ppm; mean +/- SD, 61 +/- 24 ppm) served as the experimental group and 47 nonexposed students served as the control group.
A battery of neuropsychological tests was administered to each participant including digit span, the revised Wechsler Memory Scale for verbal and figural memory, Trail-Making Test parts A and B, digit symbol, block design, and the Rey Auditory Verbal Learning Test.
Venous blood carboxyhemoglobin (Hbco) levels in participants of the study group ranged from 0.01 to 0.11 (mean +/- SD, 0.04 +/- 0.03) and correlated with air carbon monoxide concentrations (r = 0.39; P = .01). The experimental group scored significantly lower than controls on the following tests: digit span forward (P = .02), short-term (P = .008) and long-term semantic memory (P = .008), digit symbol (P = .004), block design (P = .009), recall of figural memory (P = .02), and Trail-Making part A (P = .04). No significant differences were found between the experimental and control groups in other tests.
The lower scores on neuropsychological tests indicate dysfunctions in memory, new learning ability, attention and concentration, tracking skills, visuomotor skills, abstract thinking, and visuospatial planing and processing. These dysfunctions correspond with previous reports of carbon monoxide neurotoxic effects in patients with moderate carbon monoxide poisoning. Low-level exposure to carbon monoxide results in impairment of higher cognitive functions. Neuropsychological testing appears to be sensitive in the detection of subtle neurologic dysfunctions resulting from carbon monoxide poisoning.
研究急性低水平一氧化碳暴露对健康人高级认知功能的影响。
一项关于低水平一氧化碳暴露对年轻健康志愿者及配对的未暴露对照组高级认知功能影响的实证研究。
以色列耶路撒冷希伯来大学校园的一间宿舍。
45名学生志愿者作为实验组，他们暴露于家用煤油炉产生的一氧化碳中1.5至2.5小时（空气中一氧化碳浓度为17 - 100 ppm；均值±标准差，61±24 ppm），47名未暴露的学生作为对照组。
对每位参与者进行一系列神经心理学测试，包括数字广度、修订版韦氏记忆量表的言语和图形记忆、连线测验A和B部分、数字符号、积木图案、以及雷氏听觉词语学习测验。
研究组参与者静脉血中碳氧血红蛋白（Hbco）水平在0.01至0.11之间（均值±标准差，0.04±0.03），且与空气中一氧化碳浓度相关（r = 0.39；P = 0.01）。实验组在以下测试中的得分显著低于对照组：顺背数字广度（P = 0.02）、短期（P = 0.008）和长期语义记忆（P = 0.008）、数字符号（P = 0.004）、积木图案（P = 0.009）、图形记忆回忆（P = 0.02）以及连线测验A部分（P = 0.04）。实验组与对照组在其他测试中未发现显著差异。
神经心理学测试得分较低表明在记忆、新学习能力、注意力与专注力、追踪技能、视运动技能、抽象思维以及视觉空间规划与处理方面存在功能障碍。这些功能障碍与先前关于中度一氧化碳中毒患者一氧化碳神经毒性作用的报道一致。低水平一氧化碳暴露会导致高级认知功能受损。神经心理学测试似乎对检测一氧化碳中毒引起的细微神经功能障碍很敏感。
