Kitchens G G, Gross C W
Arch Otolaryngol. 1976 Sep;102(9):547-51. doi: 10.1001/archotol.1976.00780140079009.
The section of the cat's mesotympanum, denuded of mucosa, to Silastic and gelatin film was studied and compared with the contralateral control ear, which was also denuded of mucosa. The ears were studied by horizontal pathological sections taken one, two, four, and six months post-lympanotomy and insertion of either gelatin film or Silastic. The Silastic, gelatin film and control ears were compared for inflammatory reaction, amount of fibrosis, and the quality and quantity of mucosal regeneration. The inflammatory reaction was increased in the ears with Silastic compared with their corresponding control ears or to the ears with gelatin film. The amount of fibrosis and the quality and quantity of mucosal regeneration was essentially the same in the Silastic, gelatin film, and control ears. This study shows that both substances are well tolerated in the middle ear and that neither substance stimulated or inhibited the regrowth of mucosa or fibrous tissue when compared with the control.
对去除了黏膜的猫的中鼓室部分植入硅橡胶和明胶薄膜，并与同样去除了黏膜的对侧对照耳进行研究和比较。在淋巴鼓室造口术并植入明胶薄膜或硅橡胶后的1个月、2个月、4个月和6个月，通过水平病理切片对耳朵进行研究。比较硅橡胶组、明胶薄膜组和对照组耳朵的炎症反应、纤维化程度以及黏膜再生的质量和数量。与相应的对照耳或明胶薄膜组耳朵相比，植入硅橡胶的耳朵炎症反应增强。硅橡胶组、明胶薄膜组和对照组耳朵的纤维化程度以及黏膜再生的质量和数量基本相同。这项研究表明，两种物质在中耳均具有良好的耐受性，与对照组相比，两种物质均未刺激或抑制黏膜或纤维组织的再生。
