Delva P, Pastori C, Degan M, Montesi G, Lechi A
Institute of Internal Medicine, University of Verona, Policlinico Borgo Roma, Italy.
Life Sci. 1998;62(24):2231-40. doi: 10.1016/s0024-3205(98)00201-x.
To evaluate the relative effect of hypertension and plasma triglycerides on intralymphocyte magnesium we measured ionized intralymphocyte magnesium (Mg(i)) concentration by means of a fluorimetric method based on the dye Furaptra in 4 groups of subjects: 18 normotensive normotriglyceridemic controls (NTNC), 9 hypertriglyceridemic normotensive patients (HTN), 8 hypertriglyceridemic essential hypertensive patients (HTEH), 17 normotriglyceridemic essential hypertensive patients (NTEH). Hypercholesterolemic, diabetic patients and alcoholics were excluded from the study. Mg(i) was found to be statistically reduced (ANOVA test F=10.41, P=0.0001) in both HTN and HTEH (M+/- SD, HTN: 0.235 +/- 0.01, HTEH: 0.236 +/- 0.01 mmol/l) as compared to both NTNC and NTEH (M +/- SD, NTNC: 0.294 +/- 0.008, NTEH: 0.297 +/- 0.009 mmol/l). A statistically significant negative correlation was found in the population as a whole between Mg(i) and plasma triglycerides (n=52, R= -541, P=0.00004). Our data suggest that hypertriglyceridemia per se and possibly the so-called plurimetabolic syndrome is characterized by low intralymphocyte free magnesium.
为了评估高血压和血浆甘油三酯对淋巴细胞内镁的相对影响，我们采用基于Furaptra染料的荧光法，对4组研究对象的淋巴细胞内游离镁（Mg(i)）浓度进行了测量：18名血压正常、甘油三酯正常的对照者（NTNC），9名甘油三酯血症但血压正常的患者（HTN），8名甘油三酯血症的原发性高血压患者（HTEH），17名甘油三酯正常的原发性高血压患者（NTEH）。高胆固醇血症患者、糖尿病患者和酗酒者被排除在研究之外。结果发现，与NTNC组和NTEH组相比，HTN组和HTEH组的Mg(i)均有统计学意义的降低（方差分析F=10.41，P=0.0001）（均值±标准差，HTN组：0.235±0.01，HTEH组：0.236±0.01 mmol/L），NTNC组：0.294±0.008，NTEH组：0.297±0.009 mmol/L）。在整个研究人群中，Mg(i)与血浆甘油三酯之间存在统计学意义的负相关（n=52，R= -541，P=0.00004）。我们的数据表明，高甘油三酯血症本身以及可能的所谓多代谢综合征的特征是淋巴细胞内游离镁含量低。
