20天卧床休息对健康年轻受试者逆向胆固醇转运系统的影响。

Effect of 20 days' bed rest on the reverse cholesterol transport system in healthy young subjects.

作者信息

Yanagibori R, Kondo K, Suzuki Y, Kawakubo K, Iwamoto T, Itakura H, Gunji A

机构信息

Aichi Prefectural College of Nursing and Health, Nagoya, Japan.

出版信息

J Intern Med. 1998 Apr;243(4):307-12. doi: 10.1046/j.1365-2796.1998.00303.x.

DOI:10.1046/j.1365-2796.1998.00303.x

PMID:9627145

Abstract

OBJECTIVES

To study the effects of 20 days of bed rest on HDL cholesterol, lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase.

DESIGN

A 20-day intervention study.

SETTING

Makita general hospital.

SUBJECTS

Five male and five female healthy participants, mean age 20.4 years, range 19-24 years.

INTERVENTIONS

Twenty days of bed rest.

MAIN OUTCOME MEASURES

Lipid, lipoprotein, lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase.

RESULTS

Fasting HDL, HDL2 and HDL3 cholesterol levels decreased from 1.748 to 1.404 mmol L(-1) (P < 0.01), from 0.807 to 0.628 mmol L(-1) (P < 0.01) and from 0.939 to 0.784 mmol L(-1) (P < 0.05), respectively, while VLDL triglyceride levels increased from 0.365 to 0.754 mmol L(-1) (P < 0.05). Plasma post-heparin lipoprotein lipase activity decreased from 0.494 to 0.418 micromol mL(-1) h(-1) (P < 0.01), but plasma post-heparin hepatic triglyceride lipase activity and cholesterol ester transfer protein activity did not change during bed rest. Lecithin-cholesterol acyltransferase activity increased from 72.5 to 84.8 nmol mL(-1) h(-1) (P < 0.001).

CONCLUSIONS

Twenty days of bed rest induced a decline in HDL cholesterol levels and an increase in VLDL triglyceride levels. When considering lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase as factors in the decreased HDL cholesterol, the contribution of lipoprotein lipase is suggested.

摘要

目的

研究20天卧床休息对高密度脂蛋白胆固醇、脂蛋白脂肪酶、肝甘油三酯脂肪酶、胆固醇酯转运蛋白和卵磷脂胆固醇酰基转移酶的影响。

设计

一项为期20天的干预研究。

地点

牧田综合医院。

研究对象

5名男性和5名女性健康参与者，平均年龄20.4岁，年龄范围19 - 24岁。

干预措施

20天卧床休息。

主要观察指标

脂质、脂蛋白、脂蛋白脂肪酶、肝甘油三酯脂肪酶、胆固醇酯转运蛋白和卵磷脂胆固醇酰基转移酶。

结果

空腹高密度脂蛋白、高密度脂蛋白2和高密度脂蛋白3胆固醇水平分别从1.748 mmol/L降至1.404 mmol/L（P < 0.01），从0.807 mmol/L降至0.628 mmol/L（P < 0.01），从0.939 mmol/L降至0.784 mmol/L（P < 0.05），而极低密度脂蛋白甘油三酯水平从0.365 mmol/L升至0.754 mmol/L（P < 0.05）。血浆肝素后脂蛋白脂肪酶活性从0.494 μmol/mL·h降至0.418 μmol/mL·h（P < 0.01），但卧床休息期间血浆肝素后肝甘油三酯脂肪酶活性和胆固醇酯转运蛋白活性未发生变化。卵磷脂胆固醇酰基转移酶活性从72.5 nmol/mL·h升至84.8 nmol/mL·h（P < 0.001）。