Tadamura E, Kitano H, Kudoh T, Hattori N, Inubushi M, Nishimura K, Masuda I, Inada H, Hosokawa R, Nohara R, Konishi J
Department of Nuclear Medicine, Kyoto University Faculty of Medicine, Japan.
J Nucl Med. 1998 Jun;39(6):938-44.
The purpose of this study was to validate the accuracy of the assessment of ventricular function by first-pass radionuclide angiography (FPRNA) with 123I myocardial tracers and a multicrystal gamma camera.
Left ventricular ejection fraction (LVEF) and right ventricular ejection fraction were measured in 69 patients by FPRNA using 123I myocardial tracers (126 +/- 7 MBq) and 99mTc tracers (541 +/- 141 MBq) on a multicrystal gamma camera with a high-sensitivity collimator. For 44 patients, ejection fraction values measured by 123I-FPRNA were compared to those estimated by equilibrium radionuclide angiography (ERNA). Visual wall-motion analysis was also performed to judge clinical acceptability of 123I-FPRNA images for identification of wall-motion abnormality.
Mean LVEFs (%) estimated by 123I-FPRNA and by 99mTc-FPRNA were 49.6 +/- 13.6 and 49.1 +/- 14.1, respectively (nonsignificant p value). An excellent correlation was found between LVEFs estimated by 123I-FPRNA and 99mTc-FPRNA (r = 0.96, s.e.e. = 1.9%). Values of LVEF measured by 123I-FPRNA also demonstrated excellent correlation with those measured by ERNA (r = 0.95, s.e.e. = 2.2%). A good correlation was also noted between right ventricular ejection fractions measured by 123I-FPRNA and 99mTc-FPRNA (r = 0.72, s.e.e. = 4.0%). The Spearman rank correlation coefficient between 123I-FPRNA and ERNA wall-motion scores was 0.87 (n = 135, p < 0.001).
Resting ventricular function can be reliably measured with 123I-FPRNA in combination with a multicrystal gamma camera. This indicates that the assessment of ventricular function is feasible in conjunction with 123I myocardial imaging without an increase in cost or radiation dose to patients.
本研究的目的是验证使用123I心肌示踪剂和多晶体γ相机进行首次通过放射性核素血管造影（FPRNA）评估心室功能的准确性。
在一台配备高灵敏度准直器的多晶体γ相机上，使用123I心肌示踪剂（126±7MBq）和99mTc示踪剂（541±141MBq），通过FPRNA对69例患者的左心室射血分数（LVEF）和右心室射血分数进行测量。对44例患者，将123I-FPRNA测量的射血分数值与平衡放射性核素血管造影（ERNA）估计的值进行比较。还进行了视觉壁运动分析，以判断123I-FPRNA图像用于识别壁运动异常的临床可接受性。
123I-FPRNA和99mTc-FPRNA估计的平均LVEF（%）分别为49.6±13.6和49.1±14.1（p值无显著性差异）。123I-FPRNA和99mTc-FPRNA估计的LVEF之间发现了极好的相关性（r = 0.96，标准误差 = 1.9%）。123I-FPRNA测量的LVEF值与ERNA测量的值也显示出极好的相关性（r = 0.95，标准误差 = 2.2%）。123I-FPRNA和99mTc-FPRNA测量的右心室射血分数之间也发现了良好的相关性（r = 0.72，标准误差 = 4.0%）。123I-FPRNA和ERNA壁运动评分之间的Spearman等级相关系数为0.87（n = 135，p < 0.001）。
123I-FPRNA结合多晶体γ相机可可靠地测量静息心室功能。这表明在不增加患者成本或辐射剂量的情况下，结合123I心肌成像评估心室功能是可行的。
