Zarić J, Lazić D, Marković S, Glisin V, Ivanović Z, Milenković P, Popović Z
Institute of Molecular Genetics and Genetic Engineering, Belgrade, Yugoslavia.
Hemoglobin. 1998 May;22(3):231-44. doi: 10.3109/03630269809113137.
We have studied the changes in bone marrow and spleen globin chain levels after in vivo hemin and iron-dextran treatment of hereditarily anemic Belgrade laboratory (b/b) rats. The increase of globin chains was detected in the bone marrow and in the spleen when b/b animals were treated with either iron or hemin. The analysis of changes in alpha- and beta-globin chain ratios revealed the distinctive role of these molecules in regulating globin chain status. Iron-dextran, as expected, ameliorated the imbalance of alpha- and beta-globin chains in the b/b rat spleen. On the other hand, hemin, as we have hypothesized in the accompanying paper, leads to a surplus of beta-globin chains in the bone marrow, similar to the one detected in the b/b rat spleen. Therefore, an iron-rich microenvironment has a stimulatory effect, while a hemin-rich microenvironment has an inhibitory effect on erythropoiesis.
我们研究了遗传性贫血的贝尔格莱德实验大鼠（b/b）在体内接受氯高铁血红素和右旋糖酐铁治疗后骨髓和脾脏中珠蛋白链水平的变化。当用铁或氯高铁血红素处理b/b动物时，在骨髓和脾脏中均检测到珠蛋白链增加。对α和β珠蛋白链比例变化的分析揭示了这些分子在调节珠蛋白链状态中的独特作用。正如预期的那样，右旋糖酐铁改善了b/b大鼠脾脏中α和β珠蛋白链的失衡。另一方面，正如我们在随附论文中所假设的，氯高铁血红素导致骨髓中β珠蛋白链过剩，类似于在b/b大鼠脾脏中检测到的情况。因此，富含铁的微环境对红细胞生成具有刺激作用，而富含氯高铁血红素的微环境则具有抑制作用。
