Taylor G A, Moore P B, Ferrier I N, Tyrer S P, Edwardson J A
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle Upon Tyne, UK.
J Inorg Biochem. 1998 Feb 15;69(3):165-9. doi: 10.1016/s0162-0134(97)10014-9.
Aluminium (Al) is an abundant terrestrial element, but toxic to tissues, including brain. The body is largely protected because systemic Al absorption is very low and in normal individuals almost all absorbed Al is excreted from the body. However gastrointestinal (Gl) absorption is enhanced by organic acids, including citrate. Aluminium and citrate Gl absorption was measured in three healthy males, aged 40-46. After overnight fast, subjects drank a 100 ml fruit drink containing 280 mg Al and 3.2 g citrate (104 and 167 mM, respectively). Al was measured in timed blood and urine samples by GFAAS and serum citrate by enzymatic assay. Blood Al peaked by an increase of 13 +/- 2.1 micrograms/l after 87 +/- 19 min then fell slowly over 24 h. Plasma citrate peaked after 32 min, returning to baseline by 90 min. Al was excreted at a constant rate for the first 24 h, 0.4% of the dose being excreted in urine by this time. It is unlikely that Al is absorbed as Al citrate because the blood citrate peak preceded the Al peak by 45-60 min.
铝（Al）是一种地球上含量丰富的元素，但对包括大脑在内的组织有毒性。人体在很大程度上受到保护，因为全身铝的吸收非常低，在正常个体中，几乎所有吸收的铝都会从体内排出。然而，包括柠檬酸在内的有机酸会增强胃肠道（Gl）的吸收。在三名年龄在40 - 46岁的健康男性中测量了铝和柠檬酸的胃肠道吸收情况。经过一夜禁食后，受试者饮用了100毫升含有280毫克铝和3.2克柠檬酸（分别为104和167毫摩尔）的果汁饮料。通过石墨炉原子吸收光谱法（GFAAS）在定时采集的血液和尿液样本中测量铝，通过酶法测定血清柠檬酸。血液中的铝在87±19分钟后达到峰值，增加了13±2.1微克/升，然后在24小时内缓慢下降。血浆柠檬酸在32分钟后达到峰值，到90分钟时恢复到基线水平。在最初的24小时内，铝以恒定速率排出，此时剂量的0.4%通过尿液排出。铝不太可能以柠檬酸铝的形式被吸收，因为血液中柠檬酸峰值比铝峰值提前45 - 60分钟出现。
