Morrow G R, Ballatori E, Groshen S, Olver I
University of Rochester Cancer Center, NY, USA.
Support Care Cancer. 1998 May;6(3):261-5. doi: 10.1007/s005200050164.
Various aspects of trial design and planning for clinical testing of antiemetic therapies administered to cancer patients are considered. It is generally felt that a randomized double-blind parallel-arm design is the best. Ways of achieving adequate power of such studies are discussed briefly, as is the need for previous identification of primary and secondary end-points. Finally, summary recommendations are given.
本文考虑了癌症患者使用止吐疗法进行临床试验的试验设计和规划的各个方面。一般认为随机双盲平行组设计是最佳的。简要讨论了实现此类研究足够检验效能的方法，以及预先确定主要和次要终点的必要性。最后给出了总结性建议。
