Kirsch R E, Frith L O, Saunders S J
Biochim Biophys Acta. 1976 Sep 6;442(3):437-41. doi: 10.1016/0005-2787(76)90317-8.
(1) The effect of ketoanalogues of branched-chain amino acids on albumin synthesis was examined in two biological systems using the [14C]carbonate technique. (2)alpha-Ketocaproic acid, the ketoanalogue of leucine, was able to reverse the reduced synthesis rate observed when isolated livers, from well-nourished animals were perfused with blood from rats deprived of dietary protein for 48 h. (3) A mixture of ketoanalogues of the three branched-chain amino acids, leucine, isoleucine and valine, was able to increase albumin synthesis per unit dry liver weight to above normal levels when administered intragastrically to rats 16 h after partial hepatectomy.
(1) 使用[14C]碳酸盐技术，在两个生物系统中研究了支链氨基酸酮类似物对白蛋白合成的影响。(2) 亮氨酸的酮类似物α-酮己酸，能够逆转当用来自缺乏膳食蛋白质48小时的大鼠的血液灌注营养良好动物的离体肝脏时所观察到的合成速率降低的情况。(3) 当在部分肝切除术后16小时对大鼠进行胃内给药时，亮氨酸、异亮氨酸和缬氨酸这三种支链氨基酸的酮类似物混合物能够使每单位干肝重的白蛋白合成增加至高于正常水平。
