Holt S E, Shay J W, Wright W E
Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235-9039, USA.
Nat Biotechnol. 1996 Jul;14(7):836-9. doi: 10.1038/nbt0796-836.
While there has been substantial experimental evidence in support of the telomere-telomerase hypothesis of aging and cancer, it has been suggested that the theory has been oversimplified to the exclusion of alternative mechanisms in the progression of cancer. This review strives to present an overview of some of the areas that have not been well explained and to indicate where multiple interpretations of the data are possible.
虽然有大量实验证据支持衰老和癌症的端粒-端粒酶假说，但有人认为该理论已被过度简化，排除了癌症进展中的其他机制。本综述力图概述一些尚未得到充分解释的领域，并指出哪些地方可能对数据有多种解释。
