Chen Rong, Mintseris Julian, Janin Joël, Weng Zhiping
Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA.
Proteins. 2003 Jul 1;52(1):88-91. doi: 10.1002/prot.10390.
We have developed a nonredundant benchmark for testing protein-protein docking algorithms. Currently it contains 59 test cases: 22 enzyme-inhibitor complexes, 19 antibody-antigen complexes, 11 other complexes, and 7 difficult test cases. Thirty-one of the test cases, for which the unbound structures of both the receptor and ligand are available, are classified as follows: 16 enzyme-inhibitor, 5 antibody-antigen, 5 others, and 5 difficult. Such a centralized resource should benefit the docking community not only as a large curated test set but also as a common ground for comparing different algorithms. The benchmark is available at (http://zlab.bu.edu/~rong/dock/benchmark.shtml).
我们已经开发了一个用于测试蛋白质-蛋白质对接算法的非冗余基准。目前它包含59个测试案例：22个酶-抑制剂复合物、19个抗体-抗原复合物、11个其他复合物以及7个困难测试案例。其中31个测试案例，受体和配体的未结合结构均已知，分类如下：16个酶-抑制剂、5个抗体-抗原、5个其他以及5个困难案例。这样一个集中的资源不仅作为一个大型的精选测试集，而且作为比较不同算法的共同基础，应该会使对接领域受益。该基准可在（http://zlab.bu.edu/~rong/dock/benchmark.shtml）获取。
