Regoes R R, Wodarz D, Nowak M A
Department of Zoology, University of Oxford, U.K.
J Theor Biol. 1998 Apr 21;191(4):451-62. doi: 10.1006/jtbi.1997.0617.
Earlier models of virus evolution during single infections do not include target cell limitation. Here we extend the basic mathematical framework of these theories and study the effect of target cell limitation on the evolution of antigenic variation, increasing replication rates and increasing virus load. We find that target cell limitation provides a selection pressure against antigenic diversification, and can therefore provide a limit to diversity. Antigenic diversity increases virus load; at the maximum level of antigenic diversity, virus load, too, is at a maximum.
早期关于单次感染期间病毒进化的模型未考虑靶细胞限制因素。在此，我们扩展了这些理论的基本数学框架，并研究靶细胞限制对抗原变异进化、复制速率增加以及病毒载量增加的影响。我们发现，靶细胞限制对抗原多样化形成了一种选择压力，因此可能对多样性构成限制。抗原多样性会增加病毒载量；在抗原多样性达到最高水平时，病毒载量也会达到最大值。
