白细胞介素-10水平升高与系统性红斑狼疮的疾病活动相关。

Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus.

作者信息

Park Y B, Lee S K, Kim D S, Lee J, Lee C H, Song C H

机构信息

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Clin Exp Rheumatol. 1998 May-Jun;16(3):283-8.

PMID:9631750

Abstract

OBJECTIVE

To determine serum interleukin-10 (IL-10) levels in systemic lupus erythematosus (SLE) patients and to assess their relationship with disease activity.

METHODS

Forty-one SLE patients and 35 controls were studied. Paired serum samples were collected from all SLE patients at the time of their presentation with active disease and at 4 weeks after the institution of treatment. IL-10 levels were determined in the sera and were compared with disease activity, measured using the SLE Disease Activity Index (SLEDAI) and laboratory parameters such as the circulating immune complexes (CIC), C3, C4, anti-DNA antibody, IgG, IgM, and IgA.

RESULTS

The IL-10 levels in SLE patients were significantly higher than those of controls (mean +/- SE, 29.2 +/- 6.8 vs. 3.5 +/- 0.6 pg/ml, p < 0.01). Elevated IL-10 levels correlated well with the SLEDAI in SLE patients (r = 0.46, p < 0.01), but did not correlate with other laboratory activity indices. The changes in serum IL-10 levels also correlated with the changes in the SLEDAI score during the patients' disease course (r = 0.51, p < 0.01).

CONCLUSION

Serum levels of IL-10 are elevated in SLE patients and increased IL-10 correlates well with SLE disease activity.

摘要

目的

测定系统性红斑狼疮（SLE）患者血清白细胞介素-10（IL-10）水平，并评估其与疾病活动度的关系。

方法

对41例SLE患者和35例对照者进行研究。收集所有SLE患者在疾病活动期就诊时及治疗开始4周后的配对血清样本。测定血清中IL-10水平，并与使用SLE疾病活动指数（SLEDAI）及实验室参数（如循环免疫复合物（CIC）、C3、C4、抗DNA抗体、IgG、IgM和IgA）所测量的疾病活动度进行比较。

结果

SLE患者的IL-10水平显著高于对照组（均值±标准误，29.2±6.8 vs. 3.5±0.6 pg/ml，p<0.01）。SLE患者中升高的IL-10水平与SLEDAI显著相关（r = 0.46，p<0.01），但与其他实验室活动指标无关。血清IL-10水平的变化也与患者病程中SLEDAI评分的变化相关（r = 0.51，p<0.01）。