血清白细胞介素 10 水平升高与系统性红斑狼疮患者疾病活动度增加及抗 SS-A/Ro 抗体阳性风险增加相关。
Increased Serum Interleukin 10 Levels Are Associated with Increased Disease Activity and Increased Risk of Anti-SS-A/Ro Antibody Positivity in Patients with Systemic Lupus Erythematosus.
机构信息
Individual Laboratory for Rheumatologic Diagnostics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Department of Rheumatology, Internal Medicine, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
出版信息
Biomolecules. 2023 Jun 11;13(6):974. doi: 10.3390/biom13060974.
UNLABELLED
Interleukin 10 (IL-10) plays a role in inflammation and cell-type responses. The anti-SS-A/Ro antibody contributes to leucopenia, and cutaneous and neonatal lupus.
OBJECTIVES
To evaluate the association between serum IL-10 levels and autoantibodies, disease activity and organ involvement in systemic lupus erythematosus (SLE) patients.
PATIENTS AND METHODS
We studied 200 SLE patients and 50 controls. We analyzed organ involvement, disease activity, serum IL-10 and interleukin-6 (IL-6) levels, and antinuclear and antiphospholipid antibody profiles.
RESULTS
Serum IL-10 and IL-6 levels were higher in SLE patients than in controls (all < 0.00001). Serum IL-10 levels were positively correlated with IL-6 ( < 0.00001), CRP ( < 0.00001), fibrinogen ( = 0.003), and ESR ( < 0.00001), and negatively correlated with hemoglobin ( = 0.0004) and lymphocytes ( = 0.01). Serum IL-6 levels were positively correlated with CRP ( < 0.00001), fibrinogen ( = 0.001), and ESR ( < 0.00001); and negatively correlated with hemoglobin ( = 0.008) and lymphocytes ( = 0.03). Elevated serum IL-10 levels were associated with an increased risk of anti-SS-A/Ro antibody positivity ( = 0.03). Elevated serum IL-6 levels were associated with an increased risk of heart ( = 0.007) and lung ( = 0.04) involvement.
CONCLUSIONS
In SLE patients, increased serum IL-10 levels were associated with increased disease activity and risk of anti-SS-A/Ro antibody positivity.
未标记
白细胞介素 10（IL-10）在炎症和细胞类型反应中发挥作用。抗 SS-A/Ro 抗体导致白细胞减少、皮肤和新生儿狼疮。
目的
评估血清白细胞介素 10（IL-10）水平与自身抗体、疾病活动度和系统性红斑狼疮（SLE）患者器官受累之间的关系。
患者和方法
我们研究了 200 例 SLE 患者和 50 例对照。我们分析了器官受累、疾病活动度、血清白细胞介素 10 和白细胞介素 6（IL-6）水平以及抗核和抗磷脂抗体谱。
结果
SLE 患者血清白细胞介素 10 和白细胞介素 6 水平高于对照组（均 < 0.00001）。血清白细胞介素 10 水平与白细胞介素 6（< 0.00001）、C 反应蛋白（< 0.00001）、纤维蛋白原（= 0.003）和红细胞沉降率（< 0.00001）呈正相关，与血红蛋白（= 0.0004）和淋巴细胞（= 0.01）呈负相关。血清白细胞介素 6 水平与 C 反应蛋白（< 0.00001）、纤维蛋白原（= 0.001）和红细胞沉降率（< 0.00001）呈正相关，与血红蛋白（= 0.008）和淋巴细胞（= 0.03）呈负相关。血清白细胞介素 10 水平升高与抗 SS-A/Ro 抗体阳性的风险增加相关（= 0.03）。血清白细胞介素 6 水平升高与心脏（= 0.007）和肺部（= 0.04）受累的风险增加相关。
结论
在 SLE 患者中，血清白细胞介素 10 水平升高与疾病活动度增加和抗 SS-A/Ro 抗体阳性的风险增加相关。
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