鞭毛运动的计算机模拟。IV. 振荡双态横桥模型的特性。
Computer simulation of flagellar movement. IV. Properties of an oscillatory two-state cross-bridge model.
作者信息
Brokaw C J
出版信息
Biophys J. 1976 Sep;16(9):1029-41. doi: 10.1016/S0006-3495(76)85753-0.
Abstract
A stochastic computational method is used to examine the properties of a simple two-state cross-bridge model, of a type which has been shown previously to self-oscillate without requiring any feedback control of the active process. The force transients obtained with this model show the major features observed with oscillatory insect fibrillar flight muscle. The effects of viscosity and cross-bridge detachment rate on the frequency of oscillation of the model resemble the effects of viscosity and ATP concentration on flagellar oscillation, and the relationship between turnover rate and frequency of oscillation is also consistent with observations on flagella. However, the amplitude of oscillation of the model does not show the degree of frequency-independence which is typical of flagella.
摘要
一种随机计算方法被用于研究一个简单的双态横桥模型的特性，该模型此前已被证明能够在不需要对活性过程进行任何反馈控制的情况下自我振荡。用这个模型获得的力瞬变显示出振荡昆虫纤维状飞行肌肉所观察到的主要特征。粘度和横桥解离速率对模型振荡频率的影响类似于粘度和ATP浓度对鞭毛振荡的影响，并且周转率与振荡频率之间的关系也与对鞭毛的观察结果一致。然而，该模型的振荡幅度并未表现出鞭毛典型的频率独立性程度。
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