微管相关运动中驱动蛋白的动力学图和自由能图。
Kinetic diagram and free energy diagram for kinesin in microtubule-related motility.
作者信息
Hill T L
出版信息
Proc Natl Acad Sci U S A. 1986 May;83(10):3326-30. doi: 10.1073/pnas.83.10.3326.
Abstract
The theoretical formalism that shows how biochemistry (ATPase activity) is related to mechanics in muscle contraction can be extended to the role of kinesin in microtubule-related motility. The main features added are the freedom of kinesin molecules to come and go from the motility complex and the small number of operative kinesin molecules in some systems. The starting points for this kind of approach are the kinetic diagram of biochemical states and the corresponding free energy diagram for these states. These topics are introduced and discussed here in relation to those systems that are presumed to use kinesin.
摘要
展示生物化学（ATP酶活性）如何与肌肉收缩中的力学相关的理论形式体系，可扩展到驱动蛋白在微管相关运动中的作用。增加的主要特征是驱动蛋白分子进出运动复合体的自由度以及某些系统中起作用的驱动蛋白分子数量较少。这种方法的出发点是生化状态的动力学图以及这些状态相应的自由能图。本文结合那些假定使用驱动蛋白的系统来介绍和讨论这些主题。
相似文献
1
Kinetic diagram and free energy diagram for kinesin in microtubule-related motility.微管相关运动中驱动蛋白的动力学图和自由能图。
Proc Natl Acad Sci U S A. 1986 May;83(10):3326-30. doi: 10.1073/pnas.83.10.3326.
2
Evidence that the 116 kDa component of kinesin binds and hydrolyzes ATP.驱动蛋白116 kDa组分结合并水解ATP的证据。
FEBS Lett. 1987 Sep 28;222(1):204-10. doi: 10.1016/0014-5793(87)80220-x.
3
Microtubule activation of kinesin ATPase activity.
Nature. 1987;326(6108):16-7. doi: 10.1038/326016a0.
4
Use of muscle contraction formalism for kinesin in fast axonal transport.肌肉收缩形式主义在快速轴突运输中对驱动蛋白的应用。
Proc Natl Acad Sci U S A. 1987 Jan;84(2):474-7. doi: 10.1073/pnas.84.2.474.
5
Bovine brain kinesin is a microtubule-activated ATPase.牛脑驱动蛋白是一种微管激活的ATP酶。
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8530-4. doi: 10.1073/pnas.83.22.8530.
6
Pathway of the microtubule-kinesin ATPase.微管-驱动蛋白ATP酶的途径。
Biophys J. 1995 Apr;68(4 Suppl):173S-176S; discussion 176S-179S.
7
Pathway of processive ATP hydrolysis by kinesin.驱动蛋白进行性ATP水解的途径。
Nature. 1995 Feb 23;373(6516):671-6. doi: 10.1038/373671a0.
8
Cargo-activated ATPase activity of kinesin.驱动蛋白的货物激活ATP酶活性。
Biophys J. 1995 Apr;68(4 Suppl):283S-284S; discussion 285S.
9
Modification of the microtubule-binding and ATPase activities of kinesin by N-ethylmaleimide (NEM) suggests a role for sulfhydryls in fast axonal transport.N-乙基马来酰亚胺（NEM）对驱动蛋白微管结合活性和ATP酶活性的修饰表明巯基在快速轴突运输中发挥作用。
Biochemistry. 1989 Nov 14;28(23):9006-12. doi: 10.1021/bi00449a008.
10
Purification and characterization of two monomeric kinesin constructs.两种单体驱动蛋白构建体的纯化与特性分析
Biochemistry. 1996 May 21;35(20):6321-9. doi: 10.1021/bi960017n.
引用本文的文献
1
Theoretical calculation methods for kinesin in fast axonal transport.驱动蛋白在快速轴突运输中的理论计算方法。
Proc Natl Acad Sci U S A. 1988 Jan;85(2):431-5. doi: 10.1073/pnas.85.2.431.
2
Use of muscle contraction formalism for kinesin in fast axonal transport.肌肉收缩形式主义在快速轴突运输中对驱动蛋白的应用。
Proc Natl Acad Sci U S A. 1987 Jan;84(2):474-7. doi: 10.1073/pnas.84.2.474.
本文引用的文献
1
CHROMOSOME VELOCITY DURING MITOSIS AS A FUNCTION OF CHROMOSOME SIZE AND POSITION.有丝分裂期间染色体速度与染色体大小和位置的关系
J Cell Biol. 1965 Apr;25(1):SUPPL:119-35. doi: 10.1083/jcb.25.1.119.
2
Theoretical models for cooperative steady-state ATPase activity of myosin subfragment-1 on regulated actin.肌球蛋白亚片段-1在调节型肌动蛋白上协同稳态ATP酶活性的理论模型。
Biophys J. 1981 Jul;35(1):99-112. doi: 10.1016/S0006-3495(81)84777-7.
3
Cross-bridge model of muscle contraction. Quantitative analysis.肌肉收缩的横桥模型。定量分析。
Biophys J. 1980 Feb;29(2):195-227. doi: 10.1016/S0006-3495(80)85126-5.
4
The formation, structure, and composition of the mammalian kinetochore and kinetochore fiber.哺乳动物动粒和动粒纤维的形成、结构及组成。
Int Rev Cytol. 1982;79:1-58. doi: 10.1016/s0074-7696(08)61672-1.
5
Theoretical formalism for the sliding filament model of contraction of striated muscle. Part I.横纹肌收缩的滑动丝模型的理论形式。第一部分。
Prog Biophys Mol Biol. 1974;28:267-340. doi: 10.1016/0079-6107(74)90020-0.
6
Attachment of transported vesicles to microtubules in axoplasm is facilitated by AMP-PNP.AMP-PNP可促进运输小泡与轴浆中微管的附着。
Nature. 1985;316(6029):645-7. doi: 10.1038/316645a0.
7
Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation.体外动粒的特性。II. 微管捕获与ATP依赖的转运
J Cell Biol. 1985 Sep;101(3):766-77. doi: 10.1083/jcb.101.3.766.
8
In vitro reactivation of anaphase spindle elongation using isolated diatom spindles.使用分离的硅藻纺锤体在体外重新激活后期纺锤体伸长。
Nature. 1985;316(6024):168-70. doi: 10.1038/316168a0.
9
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility.鉴定一种参与基于微管运动的新型力产生蛋白——驱动蛋白。
Cell. 1985 Aug;42(1):39-50. doi: 10.1016/s0092-8674(85)80099-4.
10
Theoretical problems related to the attachment of microtubules to kinetochores.与微管附着到动粒相关的理论问题。
Proc Natl Acad Sci U S A. 1985 Jul;82(13):4404-8. doi: 10.1073/pnas.82.13.4404.
Zotero 插件