鞭毛与肌肉中振荡的分子机制。
Molecular mechanism for oscillation in flagella and muscle.
作者信息
Brokaw C J
出版信息
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3102-6. doi: 10.1073/pnas.72.8.3102.
Abstract
Two-state models for muscle cross-bridges, of the type originally detailed by Andrew Huxley, were examined. Rate functions for cross-bridge attachment and detachment can be chosen which yield a steady-state force-velocity relationship appropriate for the spontaneous generation of oscillatory contractions. Computer simulations have been used to demonstrate oscillation of such cross-bridge systems, and to demonstrate that distribution of this type of local shear oscillation along the length of a flagellum is sufficient for the generation of propagated bending waves.
摘要
研究了最初由安德鲁·赫胥黎详细阐述的那种肌肉横桥双态模型。可以选择横桥附着和脱离的速率函数，这些函数会产生适合自发产生振荡收缩的稳态力-速度关系。计算机模拟已被用于证明这种横桥系统的振荡，并证明这种局部剪切振荡沿鞭毛长度的分布足以产生传播的弯曲波。
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