van den Bergh F, Meertens H, Moonen L, van Bunningen B, Blom A
Radiation Oncology Department, Groningen University Hospital, The Netherlands.
Radiother Oncol. 1998 Apr;47(1):85-90. doi: 10.1016/s0167-8140(97)00187-4.
The three-dimensional (3D) dose distribution in combination with 3D anatomy of 13 patients treated for cervical carcinoma with intracavitary brachytherapy was analyzed. The aim of this study was to determine the correlation between a dose value obtained from the integral dose volume histogram (DVH) of the rectum and (a) the Nederlands Kanker Instituut (NKI) point of reference for the rectum dose (R) and (b) the highest dose to the frontal rectum wall in the transverse CT slice near the top of the vagina through point R.
The correlation between the DVH rectum dose value for 2 cm3 in the highest dose region and the rectum dose at point R was poor (regression coefficient 0.50). On the contrary, however, the correlation between the DVH rectum dose value for 2 cm3 in the highest dose region and the maximum rectum dose value in a transverse CT slice through point R was good (regression coefficient 0.90).
The maximal rectum dose value obtained from a transverse CT slice near the top of the vagina through point R was found to be a more representative point for the rectal dose burden and might therefore show a good correlation with complications. The point of reference for the rectal dose (R) was found not to be a reliable estimation of the maximal dose in the rectum.
分析了13例接受腔内近距离放射治疗的宫颈癌患者的三维（3D）剂量分布与3D解剖结构。本研究的目的是确定从直肠的积分剂量体积直方图（DVH）获得的剂量值与（a）荷兰癌症研究所（NKI）直肠剂量参考点（R）以及（b）通过点R的阴道顶部附近横向CT切片中直肠前壁的最高剂量之间的相关性。
最高剂量区域中2 cm³的DVH直肠剂量值与点R处的直肠剂量之间的相关性较差（回归系数0.50）。然而，相反的是，最高剂量区域中2 cm³的DVH直肠剂量值与通过点R的横向CT切片中的最大直肠剂量值之间的相关性良好（回归系数0.90）。
从通过点R的阴道顶部附近横向CT切片获得的最大直肠剂量值被发现是直肠剂量负担更具代表性的点，因此可能与并发症显示出良好的相关性。直肠剂量参考点（R）被发现不是直肠最大剂量的可靠估计。
