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管状吞噬作用，一种中性粒细胞吞噬伯氏疏螺旋体的新方式。

Tube phagocytosis, a novel way for neutrophils to Phagocytize borrelia burgdorferi.

作者信息

Suhonen J, Hartiala K, Viljanen M K

机构信息

Department of Medical Microbiology, Turku University, Turku 20520, Finland.

出版信息

Infect Immun. 1998 Jul;66(7):3433-5. doi: 10.1128/IAI.66.7.3433-3435.1998.

DOI:10.1128/IAI.66.7.3433-3435.1998
PMID:9632618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC108365/
Abstract

Interactions between human neutrophils and Borrelia burgdorferi, the Lyme disease spirochete, were studied by dark-field microscopy combined with video technology. A previously unrecognized mechanism for neutrophils to phagocytize the spirochete was discovered. During phagocytosis, the spirochete attaches to the neutrophil head-on, the neutrophil forms a thin tubelike protrusion around the bacterium, and the fully covered spirochete is drawn into the cell.

摘要

通过暗视野显微镜结合视频技术研究了人类中性粒细胞与莱姆病螺旋体——伯氏疏螺旋体之间的相互作用。发现了一种中性粒细胞吞噬螺旋体的前所未有的机制。在吞噬过程中，螺旋体正面附着于中性粒细胞，中性粒细胞在细菌周围形成细管状突起，然后将完全被包裹的螺旋体吸入细胞内。

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本文引用的文献

1
Entry of Borrelia burgdorferi into macrophages is end-on and leads to degradation in lysosomes.伯氏疏螺旋体进入巨噬细胞是尾端先入，并导致在溶酶体中降解。
Infect Immun. 1996 Jul;64(7):2867-72. doi: 10.1128/iai.64.7.2867-2872.1996.
2
Fc- and non-Fc-mediated phagocytosis of Borrelia burgdorferi by macrophages.巨噬细胞对伯氏疏螺旋体的Fc介导和非Fc介导的吞噬作用。
J Infect Dis. 1994 Oct;170(4):890-3. doi: 10.1093/infdis/170.4.890.
3
Human phagocyte interactions with the Lyme disease spirochete.人类吞噬细胞与莱姆病螺旋体的相互作用。
Infect Immun. 1984 Nov;46(2):608-11. doi: 10.1128/iai.46.2.608-611.1984.
4
Interactions of phagocytes with the Lyme disease spirochete: role of the Fc receptor.吞噬细胞与莱姆病螺旋体的相互作用：Fc受体的作用
J Infect Dis. 1984 Oct;150(4):497-507. doi: 10.1093/infdis/150.4.497.
5
Endotoxin-induced selective dysfunction of rabbit polymorphonuclear leukocytes in response to endogenous chemotactic factors.内毒素诱导兔多形核白细胞对内源性趋化因子反应的选择性功能障碍。
Infect Immun. 1985 Nov;50(2):527-33. doi: 10.1128/iai.50.2.527-533.1985.
6
Coiling phagocytosis is the preferential phagocytic mechanism for Borrelia burgdorferi.卷曲吞噬作用是伯氏疏螺旋体的优先吞噬机制。
Infect Immun. 1992 Oct;60(10):4205-12. doi: 10.1128/iai.60.10.4205-4212.1992.
7
Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane.吞噬作用机制的研究。I. 颗粒结合配体与巨噬细胞质膜上特定受体进行周向附着的条件。
J Exp Med. 1975 Nov 1;142(5):1263-82. doi: 10.1084/jem.142.5.1263.