伯氏疏螺旋体进入巨噬细胞是尾端先入，并导致在溶酶体中降解。
Entry of Borrelia burgdorferi into macrophages is end-on and leads to degradation in lysosomes.
作者信息
Montgomery R R, Malawista S E
机构信息
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
出版信息
Infect Immun. 1996 Jul;64(7):2867-72. doi: 10.1128/iai.64.7.2867-2872.1996.
Abstract
The Lyme disease spirochete, Borrelia burgdorferi, is ingested rapidly by mouse macrophages in vitro. Spirochetes attach by their ends and become progressively coiled as they move deeper into cells. From the earliest measurements, spirochetes colocalize with a marker of endosomes and lysosomes, and degradation of spirochetes occurs within lysosomes.
摘要
莱姆病螺旋体，伯氏疏螺旋体，在体外能被小鼠巨噬细胞迅速摄取。螺旋体通过其末端附着，并在深入细胞的过程中逐渐盘绕。从最早的测量结果来看，螺旋体与内体和溶酶体的标志物共定位，并且螺旋体在溶酶体内发生降解。
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本文引用的文献
1
Borrelia burgdorferi and the macrophage: routine annihilation but occasional haven?伯氏疏螺旋体与巨噬细胞：常规的歼灭还是偶尔的庇护所？
Parasitol Today. 1994 Apr;10(4):154-7. doi: 10.1016/0169-4758(94)90268-2.
2
Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease.伯氏疏螺旋体外抗原替代的直接证明：探索莱姆病中对外膜蛋白A和C早期免疫反应的悖论。
J Exp Med. 1996 Jan 1;183(1):261-9. doi: 10.1084/jem.183.1.261.
3
Invasion of human skin fibroblasts by the Lyme disease spirochete, Borrelia burgdorferi.莱姆病螺旋体伯氏疏螺旋体对人皮肤成纤维细胞的侵袭。
J Infect Dis. 1993 May;167(5):1074-81. doi: 10.1093/infdis/167.5.1074.
4
5
Clustering of fibronectin adhesins toward Treponema denticola tips upon contact with immobilized fibronectin.与固定化纤连蛋白接触时，纤连蛋白黏附素向齿垢密螺旋体菌毛尖端聚集。
Infect Immun. 1994 Jun;62(6):2214-21. doi: 10.1128/iai.62.6.2214-2221.1994.
6
Electron microscopy of Langerhans cells and Borrelia burgdorferi in Lyme disease patients.莱姆病患者中朗格汉斯细胞和伯氏疏螺旋体的电子显微镜检查。
Zentralbl Bakteriol. 1994 Jan;280(3):348-59. doi: 10.1016/s0934-8840(11)80597-9.
7
Borrelia burgdorferi-induced ultrastructural alterations in human phagocytes: a clue to pathogenicity?伯氏疏螺旋体引起的人类吞噬细胞超微结构改变：致病性的线索？
J Pathol. 1994 Jul;173(3):269-82. doi: 10.1002/path.1711730311.
8
Fc- and non-Fc-mediated phagocytosis of Borrelia burgdorferi by macrophages.巨噬细胞对伯氏疏螺旋体的Fc介导和非Fc介导的吞噬作用。
J Infect Dis. 1994 Oct;170(4):890-3. doi: 10.1093/infdis/170.4.890.
9
Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization.缺乏外膜蛋白（Osp）的伯氏疏螺旋体突变体：生物学和免疫学特性
Infect Immun. 1995 Apr;63(4):1573-80. doi: 10.1128/iai.63.4.1573-1580.1995.
10
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Infect Immun. 1995 Jul;63(7):2478-84. doi: 10.1128/iai.63.7.2478-2484.1995.
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