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鉴定位于化脓性链球菌毒力因子编码区域的一个插入序列。

Identification of an insertion sequence located in a region encoding virulence factors of Streptococcus pyogenes.

作者信息

Berge A, Rasmussen M, Björck L

机构信息

Section for Molecular Pathogenesis, Department of Cell and Molecular Biology, Lund University, Lund, Sweden.

出版信息

Infect Immun. 1998 Jul;66(7):3449-53. doi: 10.1128/IAI.66.7.3449-3453.1998.

DOI:10.1128/IAI.66.7.3449-3453.1998
PMID:9632622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC108369/
Abstract

An insertion sequence, IS1562, was identified in a Streptococcus pyogenes strain of the clinically important M1 serotype. IS1562 is located in the mga regulon between the genes coding for the M protein and the C5a peptidase, both important virulence factors. The same or similar insertion sequences were found in most S. pyogenes strains, but the chromosomal location differed among isolates.

摘要

在临床上重要的M1血清型化脓性链球菌菌株中鉴定出一种插入序列IS1562。IS1562位于mga调控子中，在编码M蛋白和C5a肽酶的基因之间，这两种都是重要的毒力因子。在大多数化脓性链球菌菌株中发现了相同或相似的插入序列，但不同分离株之间的染色体位置有所不同。

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本文引用的文献

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Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution.致病细菌的致病岛：结构、功能及其对微生物进化的影响
Mol Microbiol. 1997 Mar;23(6):1089-97. doi: 10.1046/j.1365-2958.1997.3101672.x.
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Horizontal gene transfer among group A streptococci: implications for pathogenesis and epidemiology.A组链球菌中的水平基因转移：对发病机制和流行病学的影响。
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Characterization of IS1272, an insertion sequence-like element from Staphylococcus haemolyticus.溶血葡萄球菌中类插入序列元件IS1272的特性分析
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Protein SIC, a novel extracellular protein of Streptococcus pyogenes interfering with complement function.蛋白质SIC，一种干扰补体功能的化脓性链球菌新型细胞外蛋白。
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C5a peptidase alters clearance and trafficking of group A streptococci by infected mice.C5a肽酶改变感染小鼠对A组链球菌的清除和转运。
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