Billings C G, Howard P
Dept Medicine and Pharmacology, University of Sheffield, UK.
Monaldi Arch Chest Dis. 1998 Feb;53(1):43-9.
An allergic disposition has long been recognized as a risk factor for asthma. However, it has been suggested that, irrespective of genetic factors, exposure to environmental agents is of major importance in the development of asthma. In industrialized countries, people spend most of their time indoors and so environmental conditions inside the home may play an important role in asthma development. A review of studies examining the relationship between housing conditions and health in general or, more specifically, the relationship between respiratory symptoms/asthma and damp housing and mould has been carried out. These studies have shown that damp housing conditions are associated with increased prevalence of respiratory symptoms and asthma. The severity of asthma increases with an increasing quantity of dampness and mould in the home. It is suggested that damp conditions may, by a number of mechanisms, increase the allergenic burden so resulting in the development of asthma.
长期以来，过敏体质一直被认为是哮喘的一个风险因素。然而，有人提出，无论遗传因素如何，接触环境因素在哮喘的发病过程中至关重要。在工业化国家，人们大部分时间都待在室内，因此家庭内部的环境状况可能在哮喘发病中起重要作用。本文对研究住房条件与一般健康状况之间关系，或者更具体地说，呼吸症状/哮喘与潮湿住房及霉菌之间关系的研究进行了综述。这些研究表明，潮湿的住房条件与呼吸道症状和哮喘患病率的增加有关。随着家中潮湿和霉菌数量的增加，哮喘的严重程度也会增加。有人认为，潮湿环境可能通过多种机制增加过敏原负担，从而导致哮喘的发生。
