Wright F C, Younger R L, Riner J C, McBeth C A, Haufler M
Bull Environ Contam Toxicol. 1976 Aug;16(2):156-63. doi: 10.1007/BF01685222.
Cattle were dosed daily with a wet lead-based paint at a rate of about 6 mg of lead per kg per day for 60 weeks. The cattle did not exhibit overt symptoms of lead toxicosis. Blood and fecal samples collected during the study, and tissue samples obtained at slaughter of the animals were analyzed for lead by atomic absorption spectrophotometer equipped with a graphite furnace. Levels of lead in whole blood generally did not exceed 0.5 ppm. The residues of lead in feces reached as high as 1000 ppm. Highest residues in tissues were in calcified bone, the kidney cortex, kidney medulla, and then in liver. Residues of lead in muscle, brain, spleen, and bone marrow were similar to residues of lead in the control animal. Calves born to 2 test animals had elevated levels of lead in bone, kidney and liver.
给牛每天投喂含铅量约为6毫克/千克/天的湿基铅涂料，持续60周。这些牛未表现出明显的铅中毒症状。在研究期间采集的血液和粪便样本，以及在动物屠宰时获得的组织样本，通过配备石墨炉的原子吸收分光光度计分析铅含量。全血中的铅含量一般不超过0.5 ppm。粪便中的铅残留高达1000 ppm。组织中铅残留量最高的是钙化骨、肾皮质、肾髓质，其次是肝脏。肌肉、脑、脾和骨髓中的铅残留与对照动物中的铅残留相似。2只试验动物所生的犊牛骨骼、肾脏和肝脏中的铅含量升高。
