Schlick E, Kamran M A, Friedberg K D
Arch Toxicol. 1980 Dec;46(3-4):221-32. doi: 10.1007/BF00310438.
Lead levels in whole blood could be determined reliably up to a lower limit of 2 micrograms/100 ml blood, using a modified micromethod of the graphite tube furnace technique. Lead contents of various tissues were also determined by using the automated graphite tube furnace after wet ashing of the organs with nitric acid in autoclaves. Animal experiments with mice showed no measurable increase in blood lead level after a single, 10- or 30-days oral administration of lead in doses of 10--1000 micrograms lead acetate/kg body weight/day. However, these doses led to a rise in tissue lead content. There was a clear dependence of tissue lead content on type of organ examined, lead dose and duration of lead exposure. According to our experiments, the threshold dose which leads to a long-term increase in tissue lead content is assumed to be about 100 micrograms lead acetate/kg body weight/day, orally administered.
采用改良的石墨管炉技术微量法，可可靠测定全血中铅含量，最低检测限为2微克/100毫升血液。在用硝酸于高压灭菌器中对器官进行湿灰化处理后，使用自动石墨管炉还可测定各种组织中的铅含量。对小鼠进行的动物实验表明，以10 - 1000微克醋酸铅/千克体重/天的剂量单次、连续10天或30天经口给予铅后，血铅水平未见可测量的升高。然而，这些剂量导致组织铅含量升高。组织铅含量明显取决于所检查的器官类型、铅剂量和铅暴露持续时间。根据我们的实验，经口给予导致组织铅含量长期升高的阈剂量假定约为100微克醋酸铅/千克体重/天。
