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腹主动脉瘤破裂发生率的季节性变化。

A seasonal variation in the incidence of ruptured abdominal aortic aneurysms.

作者信息

Ballaro A, Cortina-Borja M, Collin J

机构信息

University of Oxford, Nuffield Department of Surgery, John Radcliffe Hospital, U.K.

出版信息

Eur J Vasc Endovasc Surg. 1998 May;15(5):429-31. doi: 10.1016/s1078-5884(98)80205-0.

DOI:10.1016/s1078-5884(98)80205-0
PMID:9633499
Abstract

OBJECTIVE

To discover whether there is a seasonal variation in the incidence of rupture of abdominal aortic aneurysms.

DESIGN

Deaths per month due to rupture of abdominal aortic aneurysm were analysed retrospectively using a cosinor regression model.

SETTING

England and Wales.

SUBJECTS

19,599 patients who died from rupture of abdominal aortic aneurysm between January 1991 and December 1995 according to death certification data.

INTERVENTIONS

None.

RESULTS

A seasonal variation in the incidence of rupture of abdominal aortic aneurysm occurs, with a peak in winter (p = 0.003). The ratio of rupture of abdominal aortic aneurysm in males and females decreased from more than 12 to 1 below age 60 years to less than 5 to 1 over age 80 years.

CONCLUSIONS

There is a seasonal variation in the incidence of recorded deaths from abdominal aortic aneurysm in England and Wales, with a peak of deaths in the cold winter months. The underlying cause is unknown, but hypertension and tobacco smoking are predisposing factors to aortic aneurysm rupture. Exposure to tobacco smoke is known to be greater indoors in cold weather and there is a winter peak of blood pressure in hypertensive patients.

摘要

目的

探究腹主动脉瘤破裂发生率是否存在季节性变化。

设计

使用余弦回归模型对腹主动脉瘤破裂导致的每月死亡人数进行回顾性分析。

地点

英格兰和威尔士。

研究对象

根据死亡证明数据,1991年1月至1995年12月期间19599例死于腹主动脉瘤破裂的患者。

干预措施

无。

结果

腹主动脉瘤破裂发生率存在季节性变化,冬季达到峰值(p = 0.003)。60岁以下男性与女性腹主动脉瘤破裂比例从超过12比1降至80岁以上不足5比1。

结论

在英格兰和威尔士,腹主动脉瘤记录死亡发生率存在季节性变化,寒冷冬季死亡人数达到峰值。其根本原因尚不清楚,但高血压和吸烟是主动脉瘤破裂的诱发因素。已知寒冷天气下室内接触烟草烟雾更多,高血压患者血压在冬季也会出现峰值。

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