• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease.

作者信息

Hollenbach E, Ackermann S, Hyman B T, Rebeck G W

机构信息

Alzheimer's Research Unit, Massachusetts General Hospital, Charlestown 02129, USA.

出版信息

Neurology. 1998 Jun;50(6):1905-7. doi: 10.1212/wnl.50.6.1905.

DOI:10.1212/wnl.50.6.1905
PMID:9633759
Abstract

C766T, a polymorphism in exon 3 of the gene for the low-density lipoprotein receptor-related protein (LRP), was found to be associated with late-onset Alzheimer's disease (AD). We developed a PCR-restriction enzyme-based assay to analyze this allele in 234 AD patients and 103 controls. We confirmed that the LRP C766T polymorphism was in disequilibrium with AD--the C/C genotype was present in 76% of AD patients and 60% of controls (p < 0.01); however, the LRP polymorphism did not influence age at onset of AD.

摘要

相似文献

1
Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease.
Neurology. 1998 Jun;50(6):1905-7. doi: 10.1212/wnl.50.6.1905.
2
The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease.
Neurosci Lett. 1999 Jan 4;259(1):29-32. doi: 10.1016/s0304-3940(98)00888-x.
3
Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population.日本人群中低密度脂蛋白受体相关蛋白基因多态性与晚发型阿尔茨海默病风险
Clin Genet. 2000 Oct;58(4):319-23. doi: 10.1034/j.1399-0004.2000.580410.x.
4
Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.阿尔茨海默病与低密度脂蛋白受体相关蛋白基因两个多态性之间的遗传关联研究。
Neurosci Lett. 1998 Mar 13;244(2):65-8. doi: 10.1016/s0304-3940(98)00141-4.
5
Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese.
Neurosci Lett. 1998 May 8;247(1):33-6. doi: 10.1016/s0304-3940(98)00294-8.
6
Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease.低密度脂蛋白受体相关蛋白基因多态性与阿尔茨海默病无关联。
Arch Neurol. 1997 Oct;54(10):1289-92. doi: 10.1001/archneur.1997.00550220087019.
7
Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.低密度脂蛋白受体相关蛋白（LRP）与阿尔茨海默病之间的关联。
Neurosci Lett. 1997 May 9;227(1):68-70. doi: 10.1016/s0304-3940(97)00304-2.
8
Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease.阿尔茨海默病中低密度脂蛋白受体相关蛋白基因外显子3多态性的病例对照研究及荟萃分析。
Neurosci Lett. 2001 Dec 4;316(1):17-20. doi: 10.1016/s0304-3940(01)02342-4.
9
Use of haplotype information to test involvement of the LRP gene in Alzheimer's disease in the French population.利用单倍型信息检测法国人群中LRP基因与阿尔茨海默病的关联。
Eur J Hum Genet. 2001 Jun;9(6):464-8. doi: 10.1038/sj.ejhg.5200644.
10
Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population.中国汉族人群中低密度脂蛋白受体相关蛋白基因多态性与阿尔茨海默病的遗传关联。
Neurosci Lett. 2008 Oct 17;444(1):109-11. doi: 10.1016/j.neulet.2008.07.093. Epub 2008 Aug 8.

引用本文的文献

1
Utilizing Proteomic Approaches to Uncover the Neuroprotective Effects of ACE Inhibitors: Implications for Alzheimer's Disease Treatment.利用蛋白质组学方法揭示 ACE 抑制剂的神经保护作用：对阿尔茨海默病治疗的启示。
Molecules. 2023 Aug 8;28(16):5938. doi: 10.3390/molecules28165938.
2
Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease.白细胞表面生物标志物提示散发性阿尔茨海默病固有免疫缺陷。
Alzheimers Dement. 2023 May;19(5):2084-2094. doi: 10.1002/alz.12813. Epub 2022 Nov 9.
3
Indomethacin Disrupts the Formation of β-Amyloid Plaques via an α2-Macroglobulin-Activating lrp1-Dependent Mechanism.
吲哚美辛通过一种α2-巨球蛋白激活的 lrp1 依赖机制破坏β-淀粉样斑块的形成。
Int J Mol Sci. 2021 Jul 30;22(15):8185. doi: 10.3390/ijms22158185.
4
Identification of LRP-1 as an endocytosis and recycling receptor for β1-integrin in thyroid cancer cells.鉴定LRP-1作为甲状腺癌细胞中β1整合素的内吞和再循环受体。
Oncotarget. 2017 Aug 10;8(45):78614-78632. doi: 10.18632/oncotarget.20201. eCollection 2017 Oct 3.
5
Association between LRP1 C766T polymorphism and Alzheimer's disease susceptibility: a meta-analysis.LRP1 C766T 多态性与阿尔茨海默病易感性的关联：荟萃分析。
Sci Rep. 2017 Aug 16;7(1):8435. doi: 10.1038/s41598-017-08335-w.
6
GC and VDR SNPs and Vitamin D Levels in Parkinson's Disease: The Relevance to Clinical Features.GC 和 VDR 单核苷酸多态性与帕金森病中的维生素 D 水平：与临床特征的相关性。
Neuromolecular Med. 2017 Mar;19(1):24-40. doi: 10.1007/s12017-016-8415-9. Epub 2016 Jun 9.
7
Genetic variant of Interleukin-18 gene is associated with the Frailty Index in the English Longitudinal Study of Ageing.白细胞介素-18基因的遗传变异与英国老龄化纵向研究中的衰弱指数相关。
Age Ageing. 2015 Nov;44(6):938-42. doi: 10.1093/ageing/afv122. Epub 2015 Sep 22.
8
APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease.载脂蛋白 E 和载脂蛋白 C1 基因多态性与中国晚发性阿尔茨海默病患者认知障碍进展相关。
Neural Regen Res. 2014 Mar 15;9(6):653-60. doi: 10.4103/1673-5374.130117.
9
Some evolutionary perspectives on Alzheimer's disease pathogenesis and pathology.阿尔茨海默病发病机制和病理学的一些进化观点。
Alzheimers Dement. 2012 Jul;8(4):343-51. doi: 10.1016/j.jalz.2011.05.2408. Epub 2011 Dec 3.
10
Increased exonic de novo mutation rate in individuals with schizophrenia.精神分裂症患者中外显子新生突变率增加。
Nat Genet. 2011 Jul 10;43(9):860-3. doi: 10.1038/ng.886.