Knudson W
Department of Biochemistry, Department of Pathology, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612-3864, USA.
Front Biosci. 1998 Jul 1;3:d604-15. doi: 10.2741/a305.
Tumor progression involves a series of complex interactions between infiltrating malignant cells and adjacent normal tissues. The cell surface receptor CD44 has been implicated as an active participant in a number of these interactions. Although assigned a variety of functions, it is the role of CD44 as a receptor for the glycosaminoglycan hyaluronan that is likely to be of most importance. The matrix macromolecule hyaluronan often becomes deposited in the tissue spaces immediately surrounding invasive tumors. As such, hyaluronan may function as a ligand for CD44-mediated locomotion or assemble into a protective matrix coat surrounding the tumor cells. Alternatively, the adjacent hyaluronan-rich matrices may serve as a barrier to migration, breached in part by aggressive cell types exhibiting a capacity for CD44-mediated hyaluronan endocytosis. The significance of tumor-associated hyaluronan accumulation as well as potential functions of CD44--hyaluronan interactions are reviewed.
肿瘤进展涉及浸润性恶性细胞与相邻正常组织之间一系列复杂的相互作用。细胞表面受体CD44被认为是其中许多相互作用的积极参与者。尽管CD44具有多种功能，但它作为糖胺聚糖透明质酸受体的作用可能最为重要。基质大分子透明质酸常常沉积在侵袭性肿瘤周围的组织间隙中。因此，透明质酸可能作为CD44介导的细胞运动的配体，或组装成围绕肿瘤细胞的保护性基质涂层。或者，相邻的富含透明质酸的基质可能作为迁移的屏障，部分被表现出CD44介导的透明质酸内吞作用能力的侵袭性细胞类型突破。本文综述了肿瘤相关透明质酸积累的意义以及CD44-透明质酸相互作用的潜在功能。
