疾病状态下红细胞锌原卟啉与原卟啉IX的比值及其在铅对血红素合成毒性机制中的意义。
The ratio of erythrocyte zinc-protoporphyrin to protoporphyrin IX in disease and its significance in the mechanism of lead toxicity on haem synthesis.
作者信息
Nelson J C, Westwood M, Allen K R, Newton K E, Barth J H
机构信息
Department of Chemical Pathology and Immunology, United Leeds Teaching Hospitals (NHS) Trust, Leeds General Infirmary, UK.
出版信息
Ann Clin Biochem. 1998 May;35 ( Pt 3):422-6. doi: 10.1177/000456329803500313.
Protoporphyrin and zinc-protoporphyrin were measured in the erythrocytes of normal subjects, workers exposed to lead and patients with iron deficiency and erythropoietic protoporphyria (EPP). Results showed significantly higher levels of zinc-protoporphyrin in the lead-exposed workers (P < 0.0001), patients with iron deficiency (P < 0.0001) and EPP patients (P < 0.001) compared with normal subjects. The lead-exposed workers showed the highest levels of zinc-protoporphyrin, which were significantly greater than both the iron-deficient and EPP patients (P < 0.0001). They also showed a higher ratio of zinc-protoporphyrin to free protoporphyrin compared with normal subjects (P < 0.0001) but no significant difference in this ratio was found when compared with iron-deficient patients (P = 0.1). These results are discussed in light of the controversy concerning the mechanism of formation of zinc-protoporphyrin in lead exposure.
在正常受试者、接触铅的工人、缺铁患者和红细胞生成性原卟啉病（EPP）患者的红细胞中测定了原卟啉和锌原卟啉。结果显示，与正常受试者相比，接触铅的工人（P < 0.0001）、缺铁患者（P < 0.0001）和EPP患者（P < 0.001）的锌原卟啉水平显著更高。接触铅的工人的锌原卟啉水平最高，显著高于缺铁患者和EPP患者（P < 0.0001）。与正常受试者相比，他们的锌原卟啉与游离原卟啉的比值也更高（P < 0.0001），但与缺铁患者相比，该比值无显著差异（P = 0.1）。根据关于铅暴露时锌原卟啉形成机制的争议对这些结果进行了讨论。
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