Lilis R, Eisinger J, Blumberg W, Fischbein A, Selikoff I J
Environ Health Perspect. 1978 Aug;25:97-102. doi: 10.1289/ehp.782597.
In a previous study of secondary lead smelter workers (males), a significant prevalence of low hemoglobin levels (less than 14 g/100 ml) was found; a statistically significant negative correlation between hemoglobin and zinc protoporphyrin was also detected. In the present study serum iron (Fe) levels and total iron binding capacity (TIBC) were included in the investigation of 111 secondary lead smelter workers and 37 nonexposed controls. The distribution and mean values of serum iron and TIBC were found to be in the normal range in the lead exposed workers; there was no significant difference when compared to the control population. There was no significant correlation between blood lead or zinc protoporphyrin and serum iron, TIBC and Fe/TIBC. A statistically significant negative correlation between hemoglobin and blood lead levels was found; the correlation between hemoglobin and zinc protoporphyrin reached a much higher level of significance. The results support the view that anemia (low hemoglobin levels) in lead exposed male workers is related to the heme synthesis inhibiting effects of lead, as reflected by elevated zinc protoporphyrin levels, and is not due to iron deficiency.
在之前一项针对二次铅冶炼厂工人（男性）的研究中，发现血红蛋白水平低（低于14 g/100 ml）的情况相当普遍；还检测到血红蛋白与锌原卟啉之间存在具有统计学意义的负相关。在本研究中，对111名二次铅冶炼厂工人和37名未接触者进行了调查，调查项目包括血清铁（Fe）水平和总铁结合力（TIBC）。发现铅暴露工人的血清铁和TIBC的分布及平均值处于正常范围；与对照人群相比无显著差异。血铅或锌原卟啉与血清铁、TIBC及铁/总铁结合力之间无显著相关性。发现血红蛋白与血铅水平之间存在具有统计学意义的负相关；血红蛋白与锌原卟啉之间的相关性达到了更高的显著水平。这些结果支持以下观点：铅暴露男性工人中的贫血（低血红蛋白水平）与铅抑制血红素合成的作用有关，这表现为锌原卟啉水平升高，而非缺铁所致。
