Di Campli C, Gasbarrini A, Nucera E, Franceschi F, Ojetti V, Sanz Torre E, Schiavino D, Pola P, Patriarca G, Gasbarrini G
Internal Medicine and Allergology Service, Catholic University, Rome, Italy.
Dig Dis Sci. 1998 Jun;43(6):1226-9. doi: 10.1023/a:1018851623109.
Helicobacter pylori, the most important cause of gastritis and peptic ulcer, recently has been associated with several extradigestive diseases. The aim of this study was to assess the prevalence of Helicobacter pylori infection and the effects of bacterium eradication in 42 consecutive patients affected by idiopathic chronic urticaria. Helicobacter pylori was assessed by [13C]urea breath test. Amoxicillin, clarithromycin, and lansoprazole were given to infected patients for seven days. Urticaria and gastrointestinal symptoms were assessed on enrollment and after eradication. Fifty-five percent of patients proved to be infected by Helicobacter pylori. Prevalence of gastrointestinal symptoms did not differ between infected and uninfected patients. Eighty-eight percent of infected patients in whom the bacterium was eradicated after therapy showed a total or partial remission of urticaria symptoms. Conversely, symptoms remained unchanged in all uninfected patients. In conclusion, Helicobacter pylori affects a high percentage of patients with idiopathic chronic urticaria; however, typical gastrointestinal symptoms do not identify infection status. Bacterium eradication is associated with a remission of urticaria symptoms, suggesting a possible role of Helicobacter pylori in the pathogenesis of this skin disorder.
幽门螺杆菌是胃炎和消化性溃疡的最重要病因，最近它还与多种消化系统外疾病有关。本研究的目的是评估42例特发性慢性荨麻疹患者中幽门螺杆菌感染的患病率以及细菌根除的效果。通过[13C]尿素呼气试验评估幽门螺杆菌。给予感染患者阿莫西林、克拉霉素和兰索拉唑治疗7天。在入组时和根除后评估荨麻疹和胃肠道症状。55%的患者被证明感染了幽门螺杆菌。感染患者和未感染患者的胃肠道症状患病率没有差异。88%在治疗后细菌被根除的感染患者荨麻疹症状完全或部分缓解。相反，所有未感染患者的症状均未改变。总之，幽门螺杆菌在特发性慢性荨麻疹患者中感染率较高；然而，典型的胃肠道症状并不能确定感染状态。细菌根除与荨麻疹症状缓解相关，提示幽门螺杆菌在这种皮肤疾病的发病机制中可能起作用。
