Li H, Baker B S
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.
Development. 1998 Jul;125(14):2641-51. doi: 10.1242/dev.125.14.2641.
The hermaphrodite (her) gene is necessary for sexual differentiation in Drosophila. Our characterization of her's zygotic function suggests that one set of female-specific terminal differentiation genes, the yolk protein (yp) genes, is transcriptionally activated by two separate pathways. One is a female-specific pathway, which is positively regulated by the female-specific doublesex protein (DSXF). The other is a non-sex-specific pathway, that is positively regulated by HER. The HER pathway is prevented from functioning in males by the action of the male-specific doublesex protein (DSXM). The HER and DSX pathways also function independently to control downstream target genes in the precursor cells that give rise to the vaginal teeth and dorsal anal plate of females, and the lateral anal plates of males. However, a female-specific pathway that is dependent on both DSXF and HER controls the female-specific differentiation of the foreleg bristles and tergites 5 and 6, and the male-specific differentiation of these tissues does not require the suppression of HER's function by DSXM.
雌雄同体基因（her）对果蝇的性别分化至关重要。我们对her合子功能的表征表明，一组雌性特异性终末分化基因，即卵黄蛋白（yp）基因，通过两条独立的途径被转录激活。一条是雌性特异性途径，由雌性特异性双性蛋白（DSXF）正向调控。另一条是非性别特异性途径，由HER正向调控。雄性特异性双性蛋白（DSXM）的作用可阻止HER途径在雄性中发挥作用。HER和DSX途径也独立发挥作用，以控制雌性阴道齿和背肛板以及雄性侧肛板的前体细胞中的下游靶基因。然而，一条同时依赖DSXF和HER的雌性特异性途径控制前腿刚毛以及第5和第6背板的雌性特异性分化，而这些组织的雄性特异性分化并不需要DSXM抑制HER的功能。
