Kirschner D E, Mehr R, Perelson A S
Department of Microbiology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1;18(2):95-109. doi: 10.1097/00042560-199806010-00001.
Several lines of evidence suggest that HIV-1 is present in the thymus during HIV-1 infection. Precursors to mature CD4+ T lymphocytes develop in the thymus, which suggests that thymic infection may play a role in the CD4+ T-cell decline observed during the course of pediatric HIV-1 infection. We illustrate, through mathematical modeling, the potential effects of thymic infection on the course of pediatric AIDS disease progression. We find that infection in the thymus not only can supplement peripheral infection but can help explain the faster progression in pediatric cases, as well as the early and high viral burden.
多项证据表明，在HIV-1感染期间，胸腺中存在HIV-1。成熟CD4+ T淋巴细胞的前体在胸腺中发育，这表明胸腺感染可能在小儿HIV-1感染过程中观察到的CD4+ T细胞减少中起作用。我们通过数学建模说明了胸腺感染对小儿艾滋病疾病进展过程的潜在影响。我们发现，胸腺感染不仅可以补充外周感染，还可以帮助解释小儿病例中更快的疾病进展以及早期和高病毒载量。
