在体外，非合胞体诱导型成人及儿童1型人类免疫缺陷病毒分离株使用除CCR5之外的共受体的情况很少见。
Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro.
作者信息
Zhang Y J, Dragic T, Cao Y, Kostrikis L, Kwon D S, Littman D R, KewalRamani V N, Moore J P
机构信息
Aaron Diamond AIDS Research Center, The Rockefeller University, New York University School of Medicine, New York, New York 10016, USA.
出版信息
J Virol. 1998 Nov;72(11):9337-44. doi: 10.1128/JVI.72.11.9337-9344.1998.
Abstract
We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed V28, and one (DH123) used CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal isolates, which were syncytium inducing, also used CXCR4, CCR8, V28, and APJ.
摘要
我们检测了一组儿科和成人的1型人类免疫缺陷病毒（HIV-1）原代分离株在病毒进入过程中利用以下蛋白质作为共受体的能力：CCR1、CCR2b、CCR3、CCR4、CCR5、CCR8、CXCR4、Bonzo、BOB、GPR1、V28、US28和APJ。大多数非合胞体诱导分离株仅能利用CCR5。所有合胞体诱导病毒都使用CXCR4，有些还利用V28，还有一株（DH123）也使用CCR8和APJ。来自一名受感染婴儿及其母亲的一系列纵向HIV-1 B亚型分离株有效地利用了Bonzo以及CCR5。具有合胞体诱导能力的母亲的分离株还使用CXCR4、CCR8、V28和APJ。
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