Zhang Y J, Dragic T, Cao Y, Kostrikis L, Kwon D S, Littman D R, KewalRamani V N, Moore J P
Aaron Diamond AIDS Research Center, The Rockefeller University, New York University School of Medicine, New York, New York 10016, USA.
J Virol. 1998 Nov;72(11):9337-44. doi: 10.1128/JVI.72.11.9337-9344.1998.
We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed V28, and one (DH123) used CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal isolates, which were syncytium inducing, also used CXCR4, CCR8, V28, and APJ.
我们检测了一组儿科和成人的1型人类免疫缺陷病毒（HIV-1）原代分离株在病毒进入过程中利用以下蛋白质作为共受体的能力：CCR1、CCR2b、CCR3、CCR4、CCR5、CCR8、CXCR4、Bonzo、BOB、GPR1、V28、US28和APJ。大多数非合胞体诱导分离株仅能利用CCR5。所有合胞体诱导病毒都使用CXCR4，有些还利用V28，还有一株（DH123）也使用CCR8和APJ。来自一名受感染婴儿及其母亲的一系列纵向HIV-1 B亚型分离株有效地利用了Bonzo以及CCR5。具有合胞体诱导能力的母亲的分离株还使用CXCR4、CCR8、V28和APJ。
