[Study on EEG patterns of schizophrenics--with use of FFT dipole approximation].

EEG recording were performed in 22 non-treated schizophrenics; subsequently, the combination of traditional EEG frequency analysis with FFT Dipole Approximation as a new method for EEG analysis was employed to determine power spectra of baseline EEGs and three dimensional model dipole source location in anterior-posterior, left-right and superior-inferior directions with changing the frequency by 0.5 Hz. Quantitative EEG study included comparison of baseline EEGs between normal volunteers and schizophrenics; the results obtained in this study coincided with previous and reports in increase of slow wave, decrease of alpha band and increase of fast wave. Dipole source location in schizophrenics were generally shifted more towards superior and posterior areas compared with those in normal volunteers whereas no shifts towards left-right areas were evidenced in schizophrenics. Seven patients on monotherapy of haloperidol were subjected to determination of dipole source location two weeks after commencement of the medication. After treatment, the source locations shifted towards anterior and inferior area, approaching to the dipole source locations in normal volunteers. Baseline dipole source locations were negatively correlated with both positive symptom rating score and negative symptom rating score according to BPRS, indicating that with increasing positive symptom rating score, the source location shifted towards posterior direction, and higher negative symptoms rating scores were associated with a shift towards right direction. These findings support our view that negative symptoms and positive symptoms might be associated with frontal lobe dysfunction theory and temporal lobe dysfunction theory.