Haller O, Frese M, Kochs G
Department of Virology, University of Freiburg, Germany.
Rev Sci Tech. 1998 Apr;17(1):220-30. doi: 10.20506/rst.17.1.1084.
Mx proteins are interferon-induced members of the dynamin superfamily of large guanosine triphosphatases. These proteins have attracted attention because some display antiviral activity against pathogenic RNA viruses, for example against members of the orthomyxovirus (influenzavirus) family or the bunyavirus family. Transfected cells and transgenic mice expressing Mx proteins are highly resistant to Mx-sensitive viruses, demonstrating that Mx proteins are powerful antiviral agents. In humans, synthesis of MxA is observed during self-limiting viral infections and may thus promote recovery from disease.
Mx蛋白是大GTP酶发动蛋白超家族中由干扰素诱导产生的成员。这些蛋白已引起关注，因为有些对致病性RNA病毒具有抗病毒活性，例如对正粘病毒（流感病毒）家族或布尼亚病毒家族的成员。表达Mx蛋白的转染细胞和转基因小鼠对Mx敏感病毒具有高度抗性，这表明Mx蛋白是强大的抗病毒剂。在人类中，自我限制的病毒感染期间会观察到MxA的合成，因此可能促进疾病的康复。
