Crofford L J
Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0680, USA.
Am J Med Sci. 1998 Jun;315(6):359-66. doi: 10.1097/00000441-199806000-00004.
Fibromyalgia (FM) and related syndromes are poorly understood disorders that share symptoms such as pain, fatigue, sleep disturbances, and psychological distress. These syndromes are more common in women, and they are associated with psychological or physical stressors. The neuroendocrine axes are essential physiologic systems that allow for communication between the brain and the body. Interconnections among the neuroendocrine axes lead to coordinate regulation of these systems in both a positive and negative fashion. Several neuroendocrine axes have been shown to be dysfunctional in patients with FM. Although we do not yet understand the relationship between the reported disturbances of neuroendocrine function and the development or maintenance of FM and related syndromes, the authors have proposed that these abnormalities are important in symptomatic manifestations. This article reviews data showing disturbances of the neuroendocrine axes in FM and proposes a hypothesis of the development and maintenance of FM related to neuroendocrine disturbances.
纤维肌痛（FM）及相关综合征是一些尚未被充分了解的疾病，它们具有疼痛、疲劳、睡眠障碍和心理困扰等共同症状。这些综合征在女性中更为常见，且与心理或身体应激源相关。神经内分泌轴是大脑与身体之间进行沟通的重要生理系统。神经内分泌轴之间的相互联系以正负两种方式导致这些系统的协调调节。已有研究表明，FM患者的多个神经内分泌轴存在功能障碍。尽管我们尚未理解所报道的神经内分泌功能紊乱与FM及相关综合征的发生或维持之间的关系，但作者们提出，这些异常在症状表现中具有重要意义。本文回顾了显示FM中神经内分泌轴紊乱的数据，并提出了一个与神经内分泌紊乱相关的FM发生和维持的假说。
