Lauritsen J G, Friedrich U
Clin Genet. 1976 Sep;10(3):156-60. doi: 10.1111/j.1399-0004.1976.tb00028.x.
Chromosome analysis was carried out on 22 spontaneous abortuses with trisomy 16 and their parents by means of sequential Q- and C-banding techniques. In seven cases, the extra chromosome No. 16 originated from a non-disjunctional error in the first meiotic division in the mother, and in two cases from an error in the first meiotic division in the father. In two cases, non-disjunction had occurred during the second meiotic division (one in the mother and one in the father). It seems that trisomy 16, although independent of maternal age, most frequently results from a first meiotic non-disjunction in the mother.
采用连续Q带和C带技术，对22例16三体自发流产胎儿及其父母进行了染色体分析。7例中，额外的16号染色体源于母亲第一次减数分裂的不分离错误，2例源于父亲第一次减数分裂的错误。2例中，第二次减数分裂期间发生了不分离（1例在母亲，1例在父亲）。似乎16三体虽然与母亲年龄无关，但最常见的原因是母亲第一次减数分裂时的不分离。
