Nam K H, Akari H, Terao K, Ohto H, Itagaki S, Yoshikawa Y
Tsukuba Primate Center, National Institute of Infectious Diseases, Ibaraki, Japan.
Dev Comp Immunol. 1998 Mar-Apr;22(2):239-48. doi: 10.1016/s0145-305x(97)00058-x.
Recently, we have found in adult cynomolgus monkeys that substantial peripheral blood CD4+ CD8+ double-positive (DP) T lymphocytes exhibit a resting memory phenotype and increase in proportion with age. In this study, we investigated whether phenotypic changes occur in the course of the increase in proportion of the DP T cells. The results obtained from 195 clinically healthy monkeys aged from 1 month to 31 years showed that the CD29hi and CD28 subpopulation in the DP T subset increased in proportion with age and that the increase reached a plateau at six years old for the CD29hi subpopulation and at eleven years old for the CD28 one, respectively. The phenotypic alteration preceded the abrupt increase in proportion of the DP T cells and was able to be classified into four phases on the basis of the qualitative and quantitative alteration.
最近，我们在成年食蟹猴中发现，大量外周血CD4+CD8+双阳性（DP）T淋巴细胞表现出静息记忆表型，且比例随年龄增长而增加。在本研究中，我们调查了DP T细胞比例增加过程中是否发生表型变化。对195只年龄从1个月到31岁的临床健康猴子的研究结果表明，DP T亚群中的CD29hi和CD28亚群比例随年龄增加，其中CD29hi亚群在6岁时、CD28亚群在11岁时增加至平台期。表型改变先于DP T细胞比例的突然增加，并且能够根据定性和定量改变分为四个阶段。
