Casali A M, Carbone G, Cavalli G
Institute of Histology and General Embryology, University of Genova, Italy.
Histopathology. 1998 May;32(5):449-53. doi: 10.1046/j.1365-2559.1998.00399.x.
Intrahepatic bile duct volume density has been evaluated in four cases of primary sclerosing cholangitis (PSC) by applying a semiautomatic image analysis system to histological sections of surgical biopsies. Comparison was made between normal livers and cases of primary biliary cirrhosis.
A marked decrease in both bile duct volume density in liver (up to 50% of normal value) and bile duct volume density in portal tracts (up to 21% of normal value) was found. The analysis of correlations between the portal tract size and the portal tract volume fraction constituted by bile ducts confirms that the destruction mainly affects small and medium-sized ducts. The ratio of bile duct to arterial component volume fractions in portal tracts turned out to be inverted with respect to that determined in normal liver, showing a decrease of up to 30% of normal value.
The features observed in primary sclerosing cholangitis, as well as the extent of bile duct loss proved to be quite similar to what we had previously described in primary biliary cirrhosis. Thus, regardless of the causes and mechanisms leading to the bile duct loss, the quantification of ductopenia produced results which are alike for the two distinct cholestatic diseases.
通过将半自动图像分析系统应用于手术活检的组织学切片，对4例原发性硬化性胆管炎（PSC）患者的肝内胆管体积密度进行评估。并将其与正常肝脏及原发性胆汁性肝硬化病例进行比较。
发现肝脏内胆管体积密度（降至正常值的50%）和汇管区胆管体积密度（降至正常值的21%）均显著降低。对汇管区大小与由胆管构成的汇管区体积分数之间的相关性分析证实，破坏主要影响中小胆管。汇管区胆管与动脉成分体积分数之比相对于正常肝脏所确定的比值发生倒置，降低至正常值的30%。
原发性硬化性胆管炎中观察到的特征以及胆管丢失的程度与我们之前在原发性胆汁性肝硬化中所描述的非常相似。因此，无论导致胆管丢失的原因和机制如何，对于这两种不同的胆汁淤积性疾病，胆管减少的量化结果是相似的。
