Yu Z H, Chan H C
Shanghai Institute of Physiology, Academia Sinica, China.
Int J Androl. 1998 Feb;21(1):2-7. doi: 10.1046/j.1365-2605.1998.00091.x.
It has been nearly three decades since the beginning of nationwide research into gossypol as a male antifertility agent in China. Several lines of data implicating some side effects of gossypol were published which led to the termination of this area of research in China. The present review re-examines these data and points out the confusion surrounding issues such as hypokalaemia, irreversible azoospermia and other side effects. The prospects and related difficulties for gossypol as a potential male contraceptive are also discussed.
自中国开始全国性研究棉酚作为男性抗生育药物以来，已经过去了近三十年。有几篇关于棉酚某些副作用的数据发表，这导致了中国这一研究领域的终止。本综述重新审视了这些数据，并指出了围绕低钾血症、不可逆无精子症和其他副作用等问题的混乱情况。还讨论了棉酚作为潜在男性避孕药具的前景及相关困难。
