Lei T, Xue D, Adams E F, Buchfelder M, Fahlbusch R
Department of Neurosurgery, Tongji Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1997;17(2):68-71. doi: 10.1007/BF02888236.
The potential role of the protein kinase C (PKC) transduction system in controlling proliferation of human pituitary somatotrophinomas was investigated. Twenty somatotrophinomas were studied using PCR and direct sequencing methods. No point mutation within the alpha PKC gene, previously thought to be associated with invasive pituitary tumors, was found in any of the 20 somatotrophinomas. It is concluded that PKC transduction system may play an important role in controlling pituitary somatotrophinoma proliferation, but there is no correlation between invasiveness and the previously reported alpha PKC gene mutation.
研究了蛋白激酶C（PKC）转导系统在控制人垂体生长激素瘤增殖中的潜在作用。使用聚合酶链反应（PCR）和直接测序方法对20例生长激素瘤进行了研究。在这20例生长激素瘤中，均未发现先前认为与侵袭性垂体肿瘤相关的αPKC基因内的点突变。结论是，PKC转导系统可能在控制垂体生长激素瘤增殖中起重要作用，但侵袭性与先前报道的αPKC基因突变之间没有相关性。
