Pisvejc J, Hyrman V, Sikora J, Berankova A, Kobeda B, Auerova M, Sochorova V
Kuffner Sanatorium, Horni Berkovice, Czech Republic.
J ECT. 1998 Jun;14(2):68-75.
A double-blind, randomized, comparative study of the therapeutic efficacy and side effects of unilateral electroconvulsive therapy (ECT) given with two different stimulus types was carried out in the Kuffner Sanatorium, Horni Berkovice, Czech Republic. Brief or ultrabrief pulse stimuli were used in 48 hospitalized patients, ages 17-61 years, diagnosed with either schizophrenia (n = 42) or major depression (n = 6). All patients received eight unilateral treatments each. Their clinical state and presence of cognitive impairment were evaluated with a battery of tests and rating scales before ECT, after the last ECT, and 1 month later. Patients were markedly improved after the course of ECT, and the improvement was maintained 1 month later. There were no significant differences in the extent of improvement between the groups treated with brief- and ultrabrief-pulse stimuli. No deleterious effects on cognitive functions and memory were detected. In fact, there was a trend toward improvement in memory and other cognitive functions after ECT in both groups, with no significant difference between them. The two stimulus waveforms studied (brief and ultrabrief pulse) thus appear to be equally effective and free of deleterious effects on memory and cognition. The response in schizophrenic patients was remarkable and deserving of further study.
在捷克共和国霍尼贝科维采的库夫纳疗养院，开展了一项双盲、随机、比较性研究，旨在探究两种不同刺激类型的单侧电休克治疗（ECT）的疗效和副作用。48名年龄在17至61岁之间的住院患者参与了研究，他们被诊断为精神分裂症（n = 42）或重度抑郁症（n = 6）。所有患者均接受了8次单侧治疗。在ECT治疗前、最后一次ECT治疗后以及1个月后，通过一系列测试和评定量表对患者的临床状态和认知障碍情况进行了评估。经过ECT疗程后，患者有显著改善，且这种改善在1个月后得以维持。接受短脉冲和超短脉冲刺激治疗的两组患者在改善程度上没有显著差异。未检测到对认知功能和记忆有有害影响。事实上，两组患者在ECT治疗后，记忆和其他认知功能均有改善趋势，且两组之间无显著差异。因此，所研究的两种刺激波形（短脉冲和超短脉冲）似乎同样有效，且对记忆和认知无有害影响。精神分裂症患者的反应显著，值得进一步研究。
